Ageing with cystic fibrosis: challenges ahead

Sacha Spelier; Maud I.M. van der Wijst; Isabelle Fajac; Damian G. Downey

doi:10.1016/j.jcf.2025.12.015

Ageing with cystic fibrosis: challenges ahead

Sacha Spelier^*
, Maud I.M. van der Wijst
, Isabelle Fajac
, Damian G. Downey

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

As life expectancy for people with cystic fibrosis continues to improve due to advances in care and CFTR modulator therapies, age-related comorbidities are emerging as new clinical challenges. This short review summarizes insights from a symposium focusing on ageing and CF at the 20th ECFS Basic Science Conference in March 2025 in Pisa, Italy. Mechanisms of ageing and their involvement in CF disease are first outlined. We then highlight two age-associated comorbidities in CF, cardiovascular disease and colorectal cancer, and outline future research directions to clarify how CF-specific and general ageing mechanisms intersect. Understanding these processes will be crucial for tailoring long-term care strategies in the ageing CF population.

Original language	English
Number of pages	5
Journal	Journal of Cystic Fibrosis
Early online date	07 Jan 2026
DOIs	https://doi.org/10.1016/j.jcf.2025.12.015
Publication status	Early online date - 07 Jan 2026

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Comorbidities
Ageing
CVD
Cystic fibrosis
CRC

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10.1016/j.jcf.2025.12.015Licence: CC BY

Cite this

@article{019e6ccd442a4a0c94be280116e7c799,

title = "Ageing with cystic fibrosis: challenges ahead",

abstract = "As life expectancy for people with cystic fibrosis continues to improve due to advances in care and CFTR modulator therapies, age-related comorbidities are emerging as new clinical challenges. This short review summarizes insights from a symposium focusing on ageing and CF at the 20th ECFS Basic Science Conference in March 2025 in Pisa, Italy. Mechanisms of ageing and their involvement in CF disease are first outlined. We then highlight two age-associated comorbidities in CF, cardiovascular disease and colorectal cancer, and outline future research directions to clarify how CF-specific and general ageing mechanisms intersect. Understanding these processes will be crucial for tailoring long-term care strategies in the ageing CF population.",

keywords = "Comorbidities, Ageing, CVD, Cystic fibrosis, CRC",

author = "Sacha Spelier and \{van der Wijst\}, \{Maud I.M.\} and Isabelle Fajac and Downey, \{Damian G.\}",

year = "2026",

month = jan,

day = "7",

doi = "10.1016/j.jcf.2025.12.015",

language = "English",

journal = "Journal of Cystic Fibrosis",

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TY - JOUR

T1 - Ageing with cystic fibrosis: challenges ahead

AU - Spelier, Sacha

AU - van der Wijst, Maud I.M.

AU - Fajac, Isabelle

AU - Downey, Damian G.

PY - 2026/1/7

Y1 - 2026/1/7

N2 - As life expectancy for people with cystic fibrosis continues to improve due to advances in care and CFTR modulator therapies, age-related comorbidities are emerging as new clinical challenges. This short review summarizes insights from a symposium focusing on ageing and CF at the 20th ECFS Basic Science Conference in March 2025 in Pisa, Italy. Mechanisms of ageing and their involvement in CF disease are first outlined. We then highlight two age-associated comorbidities in CF, cardiovascular disease and colorectal cancer, and outline future research directions to clarify how CF-specific and general ageing mechanisms intersect. Understanding these processes will be crucial for tailoring long-term care strategies in the ageing CF population.

AB - As life expectancy for people with cystic fibrosis continues to improve due to advances in care and CFTR modulator therapies, age-related comorbidities are emerging as new clinical challenges. This short review summarizes insights from a symposium focusing on ageing and CF at the 20th ECFS Basic Science Conference in March 2025 in Pisa, Italy. Mechanisms of ageing and their involvement in CF disease are first outlined. We then highlight two age-associated comorbidities in CF, cardiovascular disease and colorectal cancer, and outline future research directions to clarify how CF-specific and general ageing mechanisms intersect. Understanding these processes will be crucial for tailoring long-term care strategies in the ageing CF population.

KW - Comorbidities

KW - Ageing

KW - CVD

KW - Cystic fibrosis

KW - CRC

U2 - 10.1016/j.jcf.2025.12.015

DO - 10.1016/j.jcf.2025.12.015

M3 - Review article

C2 - 41506936

SN - 1569-1993

JO - Journal of Cystic Fibrosis

JF - Journal of Cystic Fibrosis

ER -

Ageing with cystic fibrosis: challenges ahead

Abstract

UN SDGs

Keywords

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