Airway Epithelial Derived Cytokines and Chemokines and Their Role in the Pathogenesis of Respiratory Syncytial Virus Infection.

Research output: Contribution to journalReview article

Abstract

The airway epithelium is the primary target of respiratory syncytial virus infection. It is an important component of the antiviral immune response. It contributes to the recruitment and activation of innate immune cells from the periphery through the secretion of cytokines and chemokines. Here we provide a broad review of the cytokines and chemokines secreted from human airway epithelial cell models during RSV infection based on a comprehensive literature review. Epithelium-derived chemokines constitute most inflammatory mediators secreted from the epithelium during RSV infection. This suggests chemoattraction of peripheral immune cells, such as monocytes, neutrophils, eosinophils, and natural killer cells as a key function of the epithelium. Reports of epithelium-derived cytokines are limited. Recent research has started to identify novel cytokines, the functions of which remain largely unknown in the wider context of the RSV immune response. We argue that the correct choice of in vitro models used for investigations of epithelial immune functions during RSV infection could facilitate greater progress in this field.
Original languageEnglish
JournalPathogens
Publication statusAccepted - 17 Jul 2019

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Respiratory Syncytial Virus Infections
Chemokines
Epithelium
Cytokines
Infection
Eosinophils
Natural Killer Cells
Antiviral Agents
Monocytes
Neutrophils
Epithelial Cells
Research

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@article{13103e9820e74f28a2ffdc98ad91b678,
title = "Airway Epithelial Derived Cytokines and Chemokines and Their Role in the Pathogenesis of Respiratory Syncytial Virus Infection.",
abstract = "The airway epithelium is the primary target of respiratory syncytial virus infection. It is an important component of the antiviral immune response. It contributes to the recruitment and activation of innate immune cells from the periphery through the secretion of cytokines and chemokines. Here we provide a broad review of the cytokines and chemokines secreted from human airway epithelial cell models during RSV infection based on a comprehensive literature review. Epithelium-derived chemokines constitute most inflammatory mediators secreted from the epithelium during RSV infection. This suggests chemoattraction of peripheral immune cells, such as monocytes, neutrophils, eosinophils, and natural killer cells as a key function of the epithelium. Reports of epithelium-derived cytokines are limited. Recent research has started to identify novel cytokines, the functions of which remain largely unknown in the wider context of the RSV immune response. We argue that the correct choice of in vitro models used for investigations of epithelial immune functions during RSV infection could facilitate greater progress in this field.",
author = "Lena Glaser and Patricia Coulter and Michael Shields and Olivier Touzelet and Ultan Power and Lindsay Broadbent",
year = "2019",
month = "7",
day = "17",
language = "English",
journal = "Pathogens",
issn = "2076-0817",
publisher = "MDPI AG",

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TY - JOUR

T1 - Airway Epithelial Derived Cytokines and Chemokines and Their Role in the Pathogenesis of Respiratory Syncytial Virus Infection.

AU - Glaser, Lena

AU - Coulter, Patricia

AU - Shields, Michael

AU - Touzelet, Olivier

AU - Power, Ultan

AU - Broadbent, Lindsay

PY - 2019/7/17

Y1 - 2019/7/17

N2 - The airway epithelium is the primary target of respiratory syncytial virus infection. It is an important component of the antiviral immune response. It contributes to the recruitment and activation of innate immune cells from the periphery through the secretion of cytokines and chemokines. Here we provide a broad review of the cytokines and chemokines secreted from human airway epithelial cell models during RSV infection based on a comprehensive literature review. Epithelium-derived chemokines constitute most inflammatory mediators secreted from the epithelium during RSV infection. This suggests chemoattraction of peripheral immune cells, such as monocytes, neutrophils, eosinophils, and natural killer cells as a key function of the epithelium. Reports of epithelium-derived cytokines are limited. Recent research has started to identify novel cytokines, the functions of which remain largely unknown in the wider context of the RSV immune response. We argue that the correct choice of in vitro models used for investigations of epithelial immune functions during RSV infection could facilitate greater progress in this field.

AB - The airway epithelium is the primary target of respiratory syncytial virus infection. It is an important component of the antiviral immune response. It contributes to the recruitment and activation of innate immune cells from the periphery through the secretion of cytokines and chemokines. Here we provide a broad review of the cytokines and chemokines secreted from human airway epithelial cell models during RSV infection based on a comprehensive literature review. Epithelium-derived chemokines constitute most inflammatory mediators secreted from the epithelium during RSV infection. This suggests chemoattraction of peripheral immune cells, such as monocytes, neutrophils, eosinophils, and natural killer cells as a key function of the epithelium. Reports of epithelium-derived cytokines are limited. Recent research has started to identify novel cytokines, the functions of which remain largely unknown in the wider context of the RSV immune response. We argue that the correct choice of in vitro models used for investigations of epithelial immune functions during RSV infection could facilitate greater progress in this field.

M3 - Review article

JO - Pathogens

JF - Pathogens

SN - 2076-0817

ER -