Alcohol Consumption and Risk of Parkinson's Disease: Data from a Large Prospective European Cohort

Susan Peters; Valentina Gallo; Paolo Vineis; Lefkos T Middleton; Lars Forsgren; Carlotta Sacerdote; Sabina Sieri; Andreas Kyrozis; María-Dolores Chirlaque; Raul Zamora-Ros; Oskar Hansson; Jesper Petersson; Verena Katzke; Tilman Kühn; Olatz Mokoroa; Giovanna Masala; Eva Ardanaz; Salvatore Panico; Manuela M Bergmann; Timothy J Key; Elisabete Weiderpass; Pietro Ferrari; Roel Vermeulen

doi:10.1002/mds.28039

Alcohol Consumption and Risk of Parkinson's Disease: Data from a Large Prospective European Cohort

Susan Peters, Valentina Gallo, Paolo Vineis, Lefkos T Middleton, Lars Forsgren, Carlotta Sacerdote, Sabina Sieri, Andreas Kyrozis, María-Dolores Chirlaque, Raul Zamora-Ros, Oskar Hansson, Jesper Petersson, Verena Katzke, Tilman Kühn, Olatz Mokoroa, Giovanna Masala, Eva Ardanaz, Salvatore Panico, Manuela M Bergmann, Timothy J KeyElisabete Weiderpass, Pietro Ferrari, Roel Vermeulen

School of Biological Sciences

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Abstract

BACKGROUND: Parkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence is inconclusive.

OBJECTIVE: To assess the associations between alcohol consumption and PD risk.

METHODS: Within NeuroEPIC4PD, a prospective European population-based cohort, 694 incident PD cases were ascertained from 209,998 PD-free participants. Average alcohol consumption at different time points was self-reported at recruitment. Cox regression hazard ratios were estimated for alcohol consumption and PD occurrence.

RESULTS: No associations between baseline or lifetime total alcohol consumption and PD risk were observed. Men with moderate lifetime consumption (5-29.9 g/day) were at ~50% higher risk compared with light consumption (0.1-4.9 g/day), but no linear exposure-response trend was observed. Analyses by beverage type also revealed no associations with PD.

CONCLUSION: Our data reinforce previous findings from prospective studies showing no association between alcohol consumption and PD risk. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

Original language	English
Journal	Movement Disorders
Early online date	01 May 2020
DOIs	https://doi.org/10.1002/mds.28039
Publication status	Early online date - 01 May 2020

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10.1002/mds.28039Licence: CC BY

Alcohol Consumption and Risk of Parkinson's Disease: Data from a Large Prospective European Cohort
Copyright 2020 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 200 KBLicence: CC BY

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Peters, S., Gallo, V., Vineis, P., Middleton, L. T., Forsgren, L., Sacerdote, C., Sieri, S., Kyrozis, A., Chirlaque, M.-D., Zamora-Ros, R., Hansson, O., Petersson, J., Katzke, V., Kühn, T., Mokoroa, O., Masala, G., Ardanaz, E., Panico, S., Bergmann, M. M., ... Vermeulen, R. (2020). Alcohol Consumption and Risk of Parkinson's Disease: Data from a Large Prospective European Cohort. Movement Disorders. Advance online publication. https://doi.org/10.1002/mds.28039

@article{2df98fc072db454da1a1128ae177596b,

title = "Alcohol Consumption and Risk of Parkinson's Disease: Data from a Large Prospective European Cohort",

abstract = "BACKGROUND: Parkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence is inconclusive.OBJECTIVE: To assess the associations between alcohol consumption and PD risk.METHODS: Within NeuroEPIC4PD, a prospective European population-based cohort, 694 incident PD cases were ascertained from 209,998 PD-free participants. Average alcohol consumption at different time points was self-reported at recruitment. Cox regression hazard ratios were estimated for alcohol consumption and PD occurrence.RESULTS: No associations between baseline or lifetime total alcohol consumption and PD risk were observed. Men with moderate lifetime consumption (5-29.9 g/day) were at ~50% higher risk compared with light consumption (0.1-4.9 g/day), but no linear exposure-response trend was observed. Analyses by beverage type also revealed no associations with PD.CONCLUSION: Our data reinforce previous findings from prospective studies showing no association between alcohol consumption and PD risk. {\textcopyright} 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.",

author = "Susan Peters and Valentina Gallo and Paolo Vineis and Middleton, {Lefkos T} and Lars Forsgren and Carlotta Sacerdote and Sabina Sieri and Andreas Kyrozis and Mar{\'i}a-Dolores Chirlaque and Raul Zamora-Ros and Oskar Hansson and Jesper Petersson and Verena Katzke and Tilman K{\"u}hn and Olatz Mokoroa and Giovanna Masala and Eva Ardanaz and Salvatore Panico and Bergmann, {Manuela M} and Key, {Timothy J} and Elisabete Weiderpass and Pietro Ferrari and Roel Vermeulen",

note = "{\textcopyright} 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.",

year = "2020",

month = may,

day = "1",

doi = "10.1002/mds.28039",

language = "English",

journal = "Movement Disorders",

issn = "0885-3185",

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Peters, S, Gallo, V, Vineis, P, Middleton, LT, Forsgren, L, Sacerdote, C, Sieri, S, Kyrozis, A, Chirlaque, M-D, Zamora-Ros, R, Hansson, O, Petersson, J, Katzke, V, Kühn, T, Mokoroa, O, Masala, G, Ardanaz, E, Panico, S, Bergmann, MM, Key, TJ, Weiderpass, E, Ferrari, P & Vermeulen, R 2020, 'Alcohol Consumption and Risk of Parkinson's Disease: Data from a Large Prospective European Cohort', Movement Disorders. https://doi.org/10.1002/mds.28039

TY - JOUR

T1 - Alcohol Consumption and Risk of Parkinson's Disease: Data from a Large Prospective European Cohort

AU - Peters, Susan

AU - Gallo, Valentina

AU - Vineis, Paolo

AU - Middleton, Lefkos T

AU - Forsgren, Lars

AU - Sacerdote, Carlotta

AU - Sieri, Sabina

AU - Kyrozis, Andreas

AU - Chirlaque, María-Dolores

AU - Zamora-Ros, Raul

AU - Hansson, Oskar

AU - Petersson, Jesper

AU - Katzke, Verena

AU - Kühn, Tilman

AU - Mokoroa, Olatz

AU - Masala, Giovanna

AU - Ardanaz, Eva

AU - Panico, Salvatore

AU - Bergmann, Manuela M

AU - Key, Timothy J

AU - Weiderpass, Elisabete

AU - Ferrari, Pietro

AU - Vermeulen, Roel

PY - 2020/5/1

Y1 - 2020/5/1

N2 - BACKGROUND: Parkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence is inconclusive.OBJECTIVE: To assess the associations between alcohol consumption and PD risk.METHODS: Within NeuroEPIC4PD, a prospective European population-based cohort, 694 incident PD cases were ascertained from 209,998 PD-free participants. Average alcohol consumption at different time points was self-reported at recruitment. Cox regression hazard ratios were estimated for alcohol consumption and PD occurrence.RESULTS: No associations between baseline or lifetime total alcohol consumption and PD risk were observed. Men with moderate lifetime consumption (5-29.9 g/day) were at ~50% higher risk compared with light consumption (0.1-4.9 g/day), but no linear exposure-response trend was observed. Analyses by beverage type also revealed no associations with PD.CONCLUSION: Our data reinforce previous findings from prospective studies showing no association between alcohol consumption and PD risk. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

AB - BACKGROUND: Parkinson's disease (PD) etiology is not well understood. Reported inverse associations with smoking and coffee consumption prompted the investigation of alcohol consumption as a risk factor, for which evidence is inconclusive.OBJECTIVE: To assess the associations between alcohol consumption and PD risk.METHODS: Within NeuroEPIC4PD, a prospective European population-based cohort, 694 incident PD cases were ascertained from 209,998 PD-free participants. Average alcohol consumption at different time points was self-reported at recruitment. Cox regression hazard ratios were estimated for alcohol consumption and PD occurrence.RESULTS: No associations between baseline or lifetime total alcohol consumption and PD risk were observed. Men with moderate lifetime consumption (5-29.9 g/day) were at ~50% higher risk compared with light consumption (0.1-4.9 g/day), but no linear exposure-response trend was observed. Analyses by beverage type also revealed no associations with PD.CONCLUSION: Our data reinforce previous findings from prospective studies showing no association between alcohol consumption and PD risk. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

U2 - 10.1002/mds.28039

DO - 10.1002/mds.28039

M3 - Article

C2 - 32357270

SN - 0885-3185

JO - Movement Disorders

JF - Movement Disorders

ER -

Alcohol Consumption and Risk of Parkinson's Disease: Data from a Large Prospective European Cohort

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