alpha-Synuclein aggregation

A.M. Bodles, Brent Irvine

Research output: Contribution to journalArticlepeer-review


Alpha-synuclein is a major component of Lewy bodies in Parkinson's disease and is found associated with several other forms of dementia. As with other neurodegenerative diseases, the ability of alpha-synuclein to aggregate and form fibrillar deposits seems central to its pathology. We have defined a sequence within the NAC region of alpha-synuclein that is necessary for aggregation. Exploitation of chemically modified analogues of this peptide may produce inhibitors of aggregation.
Original languageEnglish
Pages (from-to)271-279
Number of pages9
JournalProtein and Peptide Letters
Publication statusPublished - 2004


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