Alpha7 nicotinic acetylcholine receptor gene and reduced risk of Alzheimer's disease.

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29 Citations (Scopus)

Abstract

Background: Sporadic Alzheimer's disease (AD) is a common disabling disease of complex aetiology for which there are limited therapeutic options. We sought to investigate the role of the alpha 7 nicotinic acetylcholine receptor gene (CHRNA7) in influencing risk of AD in a large population. CHRNA7 is a strong candidate gene for AD for several reasons: (1) its expression is altered differentially in the AD brain; (2) it interacts directly with beta amyloid peptide (A beta(42)); and (3) agonist activation induces several neuroprotective pathways.
Original languageEnglish
Pages (from-to)244-248
Number of pages5
JournalJournal of Medical Genetics
Volume45
Issue number4
DOIs
Publication statusPublished - Apr 2008

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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