TY - JOUR
T1 - Alpha7 nicotinic acetylcholine receptor gene and reduced risk of Alzheimer's disease.
AU - Craig, David
AU - McGuinness, Bernadette
AU - Johnston, Janet
AU - O'Neill, Francis
AU - Passmore, Peter
AU - Ritchie, C.W.
PY - 2008/4
Y1 - 2008/4
N2 - Background: Sporadic Alzheimer's disease (AD) is a common disabling disease of complex aetiology for which there are limited therapeutic options. We sought to investigate the role of the alpha 7 nicotinic acetylcholine receptor gene (CHRNA7) in influencing risk of AD in a large population. CHRNA7 is a strong candidate gene for AD for several reasons: (1) its expression is altered differentially in the AD brain; (2) it interacts directly with beta amyloid peptide (A beta(42)); and (3) agonist activation induces several neuroprotective pathways.
AB - Background: Sporadic Alzheimer's disease (AD) is a common disabling disease of complex aetiology for which there are limited therapeutic options. We sought to investigate the role of the alpha 7 nicotinic acetylcholine receptor gene (CHRNA7) in influencing risk of AD in a large population. CHRNA7 is a strong candidate gene for AD for several reasons: (1) its expression is altered differentially in the AD brain; (2) it interacts directly with beta amyloid peptide (A beta(42)); and (3) agonist activation induces several neuroprotective pathways.
UR - http://www.scopus.com/inward/record.url?scp=42049093762&partnerID=8YFLogxK
U2 - 10.1136/jmg.2007.052704
DO - 10.1136/jmg.2007.052704
M3 - Article
C2 - 18057084
SN - 0022-2593
VL - 45
SP - 244
EP - 248
JO - Journal of Medical Genetics
JF - Journal of Medical Genetics
IS - 4
ER -