ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase function

Martina de Majo, Simon D. Topp, Bradley N. Smith, Agnes L. Nishimura, Han Jou Chen, Athina Soragia Gkazi, Jack Miller, Chun Hao Wong, Caroline Vance, Frank Baas, Anneloor L.M.A. ten Asbroek, Kevin P. Kenna, Nicola Ticozzi, Alberto Garcia Redondo, Jesús Esteban-Pérez, Cinzia Tiloca, Federico Verde, Stefano Duga, Karen E. Morrison, Pamela J. ShawJanine Kirby, Martin R. Turner, Kevin Talbot, Orla Hardiman, Jonathan D. Glass, Jacqueline de Belleroche, Cinzia Gellera, Antonia Ratti, Ammar Al-Chalabi, Robert H. Brown, Vincenzo Silani, John E. Landers, Christopher E. Shaw

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Biochemistry, Genetics and Molecular Biology