TY - JOUR
T1 - Alterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study
AU - Sunnotel, O.
AU - Hiripi, L.
AU - Lagan, K.
AU - McDaid, J.R.
AU - De Leon, J.M.
AU - Miyagawa, Y.
AU - Crowe, H.
AU - Kaluskar, S.
AU - Ward, M.
AU - Scullion, C.
AU - Campbell, A.
AU - Downes, C.S.
AU - Hirst, David
AU - Barton, D.
AU - Mocanu, E.
AU - Tsujimura, A.
AU - Cox, M.B.
AU - Robson, Tracy
AU - Walsh, C.P.
PY - 2010/3/18
Y1 - 2010/3/18
N2 - Background: Male infertility is a common cause of reproductive failure in humans. In mice, targeted deletions of the genes coding for FKBP6 or FKBP52, members of the FK506 binding protein family, can result in male infertility. In the case of FKBP52, this reflects an important role in potentiating Androgen Receptor (AR) signalling in the prostate and accessory glands, but not the testis. In infertile men, no mutations of FKBP52 or FKBP6 have been found so far, but the gene for FKBP-like (FKBPL) maps to chromosome 6p21.3, an area linked to azoospermia in a group of Japanese patients.
AB - Background: Male infertility is a common cause of reproductive failure in humans. In mice, targeted deletions of the genes coding for FKBP6 or FKBP52, members of the FK506 binding protein family, can result in male infertility. In the case of FKBP52, this reflects an important role in potentiating Androgen Receptor (AR) signalling in the prostate and accessory glands, but not the testis. In infertile men, no mutations of FKBP52 or FKBP6 have been found so far, but the gene for FKBP-like (FKBPL) maps to chromosome 6p21.3, an area linked to azoospermia in a group of Japanese patients.
UR - http://www.scopus.com/inward/record.url?scp=77951203064&partnerID=8YFLogxK
U2 - 10.1186/1477-7827-8-22
DO - 10.1186/1477-7827-8-22
M3 - Article
SN - 1477-7827
VL - 8
SP - 22
EP - 30
JO - Reproductive Biology and Endocrinology
JF - Reproductive Biology and Endocrinology
M1 - 22
ER -