Alterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study

O. Sunnotel, L. Hiripi, K. Lagan, J.R. McDaid, J.M. De Leon, Y. Miyagawa, H. Crowe, S. Kaluskar, M. Ward, C. Scullion, A. Campbell, C.S. Downes, David Hirst, D. Barton, E. Mocanu, A. Tsujimura, M.B. Cox, Tracy Robson, C.P. Walsh

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23 Citations (Scopus)

Abstract

Background: Male infertility is a common cause of reproductive failure in humans. In mice, targeted deletions of the genes coding for FKBP6 or FKBP52, members of the FK506 binding protein family, can result in male infertility. In the case of FKBP52, this reflects an important role in potentiating Androgen Receptor (AR) signalling in the prostate and accessory glands, but not the testis. In infertile men, no mutations of FKBP52 or FKBP6 have been found so far, but the gene for FKBP-like (FKBPL) maps to chromosome 6p21.3, an area linked to azoospermia in a group of Japanese patients.
Original languageEnglish
Article number22
Pages (from-to)22-30
Number of pages9
JournalReproductive Biology and Endocrinology
Volume8
DOIs
Publication statusPublished - 18 Mar 2010

ASJC Scopus subject areas

  • Developmental Biology
  • Endocrinology
  • Reproductive Medicine

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    Sunnotel, O., Hiripi, L., Lagan, K., McDaid, J. R., De Leon, J. M., Miyagawa, Y., Crowe, H., Kaluskar, S., Ward, M., Scullion, C., Campbell, A., Downes, C. S., Hirst, D., Barton, D., Mocanu, E., Tsujimura, A., Cox, M. B., Robson, T., & Walsh, C. P. (2010). Alterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study. Reproductive Biology and Endocrinology, 8, 22-30. [22]. https://doi.org/10.1186/1477-7827-8-22