Altered expression of the septin gene, SEPT9, in ovarian neoplasia.

James Burrows, S. Chanduloy, A.K. Godwin, M.A. McIlhatton, H. Nagar, K. Yeates, P. Donaghy, J. Price, Patrick Johnston, Hilary Russell

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

The septin family of genes has been implicated in a variety of cellular processes including cytokinesis, membrane transport and fusion, exocytosis, and apoptosis. One member of the septin family maps to chromosome 17q25.3, a region commonly deleted in sporadic ovarian and breast tumours, and has also been identified as a fusion partner of MLL in acute myeloid leukaemias. The present study demonstrates that the pattern of expression of multiple splice variants of this septin gene is altered in ovarian tumours and cell lines. In particular, expression of the zeta transcript is detectable in the majority of tumours and cell lines, but not in a range of non-malignant adult and fetal tissues. Zeta expression is accompanied by loss of the ubiquitous beta transcript. Somatic mutations of the gene were not detected in ovarian tumours, but it was demonstrated that beta expression in tumour cell lines can be reactivated by 5-azacytidine treatment, suggesting a role for methylation in the control of expression of this gene. Copyright © 2003 John Wiley & Sons, Ltd.
LanguageEnglish
Pages581-588
Number of pages8
JournalJournal of Pathology
Volume201(4)
Issue number4
DOIs
Publication statusPublished - Nov 2003

Fingerprint

Septins
Tumor Cell Line
Gene Expression
Genes
Azacitidine
Neoplasms
Membrane Fusion
Cytokinesis
Exocytosis
Nuclear Family
Acute Myeloid Leukemia
Methylation
Fetus
Chromosomes
Apoptosis
Breast Neoplasms
Mutation

Cite this

Burrows, J., Chanduloy, S., Godwin, A. K., McIlhatton, M. A., Nagar, H., Yeates, K., ... Russell, H. (2003). Altered expression of the septin gene, SEPT9, in ovarian neoplasia. Journal of Pathology, 201(4)(4), 581-588. https://doi.org/10.1002/path.1484
Burrows, James ; Chanduloy, S. ; Godwin, A.K. ; McIlhatton, M.A. ; Nagar, H. ; Yeates, K. ; Donaghy, P. ; Price, J. ; Johnston, Patrick ; Russell, Hilary. / Altered expression of the septin gene, SEPT9, in ovarian neoplasia. In: Journal of Pathology. 2003 ; Vol. 201(4), No. 4. pp. 581-588.
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Burrows, J, Chanduloy, S, Godwin, AK, McIlhatton, MA, Nagar, H, Yeates, K, Donaghy, P, Price, J, Johnston, P & Russell, H 2003, 'Altered expression of the septin gene, SEPT9, in ovarian neoplasia.', Journal of Pathology, vol. 201(4), no. 4, pp. 581-588. https://doi.org/10.1002/path.1484

Altered expression of the septin gene, SEPT9, in ovarian neoplasia. / Burrows, James; Chanduloy, S.; Godwin, A.K.; McIlhatton, M.A.; Nagar, H.; Yeates, K.; Donaghy, P.; Price, J.; Johnston, Patrick; Russell, Hilary.

In: Journal of Pathology, Vol. 201(4), No. 4, 11.2003, p. 581-588.

Research output: Contribution to journalArticle

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Burrows J, Chanduloy S, Godwin AK, McIlhatton MA, Nagar H, Yeates K et al. Altered expression of the septin gene, SEPT9, in ovarian neoplasia. Journal of Pathology. 2003 Nov;201(4)(4):581-588. https://doi.org/10.1002/path.1484