Abstract
Rachid S, Ohlsen K, Wallner U, Hacker J, Hecker M, Ziebuhr W.
Institut für Molekulare Infektionsbiologie, D-97070 Würzburg, Germany.
Osmotic stress was found to induce biofilm formation in a Staphylococcus aureus mucosal isolate. Inactivation of a global regulator of the bacterial stress response, the alternative transcription factor sigma(B), resulted in a biofilm-negative phenotype and loss of salt-induced biofilm production. Complementation of the mutant strain with an expression plasmid encoding sigma(B) completely restored the wild-type phenotype. The combined data suggest a critical role of sigma(B) in S. aureus biofilm regulation under environmental stress conditions.
Original language | English |
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Pages (from-to) | 6824-6826 |
Number of pages | 3 |
Journal | Journal of Bacteriology |
Volume | 182(23) |
Publication status | Published - 2000 |