Alternative transcription factor sigma(B) is involved in regulation of biofilm expression in a Staphylococcus aureus mucosal isolate.

Wilma Ziebuhr

Research output: Contribution to journal › Article

179 Citations (Scopus)

Abstract

Rachid S, Ohlsen K, Wallner U, Hacker J, Hecker M, Ziebuhr W. Institut für Molekulare Infektionsbiologie, D-97070 Würzburg, Germany. Osmotic stress was found to induce biofilm formation in a Staphylococcus aureus mucosal isolate. Inactivation of a global regulator of the bacterial stress response, the alternative transcription factor sigma(B), resulted in a biofilm-negative phenotype and loss of salt-induced biofilm production. Complementation of the mutant strain with an expression plasmid encoding sigma(B) completely restored the wild-type phenotype. The combined data suggest a critical role of sigma(B) in S. aureus biofilm regulation under environmental stress conditions.
Original languageEnglish
Pages (from-to)6824-6826
Number of pages3
JournalJournal of Bacteriology
Volume182(23)
Publication statusPublished - 2000

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Biofilms
Staphylococcus aureus
Transcription Factors
Phenotype
Osmotic Pressure
Germany
Plasmids
Salts

Cite this

Ziebuhr, Wilma. / Alternative transcription factor sigma(B) is involved in regulation of biofilm expression in a Staphylococcus aureus mucosal isolate. In: Journal of Bacteriology. 2000 ; Vol. 182(23). pp. 6824-6826.
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Ziebuhr, W 2000, 'Alternative transcription factor sigma(B) is involved in regulation of biofilm expression in a Staphylococcus aureus mucosal isolate.', Journal of Bacteriology, vol. 182(23), pp. 6824-6826.

Alternative transcription factor sigma(B) is involved in regulation of biofilm expression in a Staphylococcus aureus mucosal isolate. / Ziebuhr, Wilma.

In: Journal of Bacteriology, Vol. 182(23), 2000, p. 6824-6826.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Alternative transcription factor sigma(B) is involved in regulation of biofilm expression in a Staphylococcus aureus mucosal isolate.

AU - Ziebuhr, Wilma

PY - 2000

Y1 - 2000

N2 - Rachid S, Ohlsen K, Wallner U, Hacker J, Hecker M, Ziebuhr W. Institut für Molekulare Infektionsbiologie, D-97070 Würzburg, Germany. Osmotic stress was found to induce biofilm formation in a Staphylococcus aureus mucosal isolate. Inactivation of a global regulator of the bacterial stress response, the alternative transcription factor sigma(B), resulted in a biofilm-negative phenotype and loss of salt-induced biofilm production. Complementation of the mutant strain with an expression plasmid encoding sigma(B) completely restored the wild-type phenotype. The combined data suggest a critical role of sigma(B) in S. aureus biofilm regulation under environmental stress conditions.

AB - Rachid S, Ohlsen K, Wallner U, Hacker J, Hecker M, Ziebuhr W. Institut für Molekulare Infektionsbiologie, D-97070 Würzburg, Germany. Osmotic stress was found to induce biofilm formation in a Staphylococcus aureus mucosal isolate. Inactivation of a global regulator of the bacterial stress response, the alternative transcription factor sigma(B), resulted in a biofilm-negative phenotype and loss of salt-induced biofilm production. Complementation of the mutant strain with an expression plasmid encoding sigma(B) completely restored the wild-type phenotype. The combined data suggest a critical role of sigma(B) in S. aureus biofilm regulation under environmental stress conditions.

M3 - Article

C2 - 11073930

VL - 182(23)

SP - 6824

EP - 6826

JO - Journal of Bacteriology

JF - Journal of Bacteriology

SN - 0021-9193

ER -

Ziebuhr W. Alternative transcription factor sigma(B) is involved in regulation of biofilm expression in a Staphylococcus aureus mucosal isolate. Journal of Bacteriology. 2000;182(23):6824-6826.