Aminoglycoside use in cystic fibrosis: therapeutic strategies and toxicity

Andrew Prayle, Alan R. Smyth

Research output: Contribution to journalReview articlepeer-review

84 Citations (Scopus)

Abstract

Purpose of Review: This review summarizes the recent literature regarding the uses for and toxicity of aminoglycosides in cystic fibrosis (CF). Recent Findings: Aminoglycosides are indicated in the management of acute exacerbations of CF, to control chronic infection, and to eradicate Pseudomonas aeruginosa after recent acquisition. Intravenous gentamicin is associated with increased risk of acute kidney injury, whereas intravenous tobramycin is less so. Studies regarding chronic kidney disease related to cumulative aminoglycoside exposure are currently conflicting, but a prevalence of up to 42% has been reported. A single daily dose of intravenous tobramycin is as effective as a thrice-daily regimen and is less nephrotoxic. A large paediatric series has recently reported a prevalence of hearing impairment of 4.5%, and a small adult cohort has found a 30% rate of vestibulotoxicity. Neither appears to be related to cumulative exposure. Summary: In recent years, the well known toxicities of aminoglycosides have been investigated in CF populations. It appears that intravenous tobramycin is well tolerated in the kidneys compared with gentamicin, and that cumulative exposure may result in chronic kidney disease. Hearing loss and vestibulotoxicity are also prevalent. These important epidemiological studies lay the groundwork to design interventional studies to reduce toxicity.

Original languageEnglish
Pages (from-to)604-610
Number of pages7
JournalCurrent Opinion in Pulmonary Medicine
Volume16
Issue number6
DOIs
Publication statusPublished - Nov 2010
Externally publishedYes

Keywords

  • Aminoglycosides
  • cystic fibrosis
  • hearing loss
  • kidney disease
  • toxicity

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Fingerprint

Dive into the research topics of 'Aminoglycoside use in cystic fibrosis: therapeutic strategies and toxicity'. Together they form a unique fingerprint.

Cite this