Aminoguanidine and the effects of modified LDL on cultured retinal capillary cells

T J Lyons, W Li, B Wojciechowski, M C Wells-Knecht, K J Wells-Knecht, A J Jenkins

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Compared with normal low density lipoprotein (N-LDL), LDL minimally modified in vitro by glycation, minimal oxidation, or glycoxidation (G-, MO-, GO-LDL) decreases survival of cultured retinal capillary endothelial cells and pericytes. Similar modifications occurring in vivo in diabetes may contribute to retinopathy. The goal of this study was to determine whether low concentrations of aminoguanidine might prevent cytotoxic modification of LDL and/or protect retinal capillary cells from previously modified LDL.
Original languageEnglish
Pages (from-to)1176-80
Number of pages5
JournalInvestigative ophthalmology & visual science
Volume41
Issue number5
Publication statusPublished - Apr 2000

Keywords

  • Animals
  • Capillaries
  • Cattle
  • Cell Count
  • Cells, Cultured
  • Endothelium, Vascular
  • Glycosylation
  • Guanidines
  • Lipoproteins, LDL
  • Oxidation-Reduction
  • Pericytes
  • Retinal Vessels

Fingerprint Dive into the research topics of 'Aminoguanidine and the effects of modified LDL on cultured retinal capillary cells'. Together they form a unique fingerprint.

  • Cite this

    Lyons, T. J., Li, W., Wojciechowski, B., Wells-Knecht, M. C., Wells-Knecht, K. J., & Jenkins, A. J. (2000). Aminoguanidine and the effects of modified LDL on cultured retinal capillary cells. Investigative ophthalmology & visual science, 41(5), 1176-80.