Aminoguanidine and the effects of modified LDL on cultured retinal capillary cells

T J Lyons, W Li, B Wojciechowski, M C Wells-Knecht, K J Wells-Knecht, A J Jenkins

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29 Citations (Scopus)


Compared with normal low density lipoprotein (N-LDL), LDL minimally modified in vitro by glycation, minimal oxidation, or glycoxidation (G-, MO-, GO-LDL) decreases survival of cultured retinal capillary endothelial cells and pericytes. Similar modifications occurring in vivo in diabetes may contribute to retinopathy. The goal of this study was to determine whether low concentrations of aminoguanidine might prevent cytotoxic modification of LDL and/or protect retinal capillary cells from previously modified LDL.
Original languageEnglish
Pages (from-to)1176-80
Number of pages5
JournalInvestigative ophthalmology & visual science
Issue number5
Publication statusPublished - Apr 2000


  • Animals
  • Capillaries
  • Cattle
  • Cell Count
  • Cells, Cultured
  • Endothelium, Vascular
  • Glycosylation
  • Guanidines
  • Lipoproteins, LDL
  • Oxidation-Reduction
  • Pericytes
  • Retinal Vessels


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