TY - JOUR
T1 - Aminolaevulinic acid diffusion characteristics in 'in vitro' normal human skin and actinic keratosis: implications for topical photodynamic therapy
AU - McLoone, N.
AU - Donnelly, Ryan
AU - Walsh, M.
AU - Dolan, O.M.
AU - McLoone, Sean
AU - McKenna, K.
AU - McCarron, P.A.
PY - 2008/8
Y1 - 2008/8
N2 - Background: The response rate of aminolaevulinic acid (ALA)-based photodynamic therapy (PDT) in certain subtypes of actinic keratosis (AK), such as hypertrophic and hyperkeratotic lesions, is variable, an effect attributable to a supposed lack of ALA penetration. A detailed and depth-related profile of spatial ALA permeation in AK following drug administration would lead to a greater understanding of concentrations achievable before protoporphyrin IX biosynthesis and subsequent PDT.
AB - Background: The response rate of aminolaevulinic acid (ALA)-based photodynamic therapy (PDT) in certain subtypes of actinic keratosis (AK), such as hypertrophic and hyperkeratotic lesions, is variable, an effect attributable to a supposed lack of ALA penetration. A detailed and depth-related profile of spatial ALA permeation in AK following drug administration would lead to a greater understanding of concentrations achievable before protoporphyrin IX biosynthesis and subsequent PDT.
UR - http://www.scopus.com/inward/record.url?scp=48449096747&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0781.2008.00358.x
DO - 10.1111/j.1600-0781.2008.00358.x
M3 - Article
VL - 24
SP - 183
EP - 190
JO - Photodermatology, Photoimmunology & Photomedicine
JF - Photodermatology, Photoimmunology & Photomedicine
SN - 0905-4383
IS - 4
ER -