Aminolaevulinic acid diffusion characteristics in 'in vitro' normal human skin and actinic keratosis: implications for topical photodynamic therapy

N. McLoone, Ryan Donnelly, M. Walsh, O.M. Dolan, Sean McLoone, K. McKenna, P.A. McCarron

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: The response rate of aminolaevulinic acid (ALA)-based photodynamic therapy (PDT) in certain subtypes of actinic keratosis (AK), such as hypertrophic and hyperkeratotic lesions, is variable, an effect attributable to a supposed lack of ALA penetration. A detailed and depth-related profile of spatial ALA permeation in AK following drug administration would lead to a greater understanding of concentrations achievable before protoporphyrin IX biosynthesis and subsequent PDT.
Original languageEnglish
Pages (from-to)183-190
Number of pages8
JournalPHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
Volume24
Issue number4
DOIs
Publication statusPublished - Aug 2008

ASJC Scopus subject areas

  • Immunology
  • Dermatology

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