Abstract
Background: The response rate of aminolaevulinic acid (ALA)-based photodynamic therapy (PDT) in certain subtypes of actinic keratosis (AK), such as hypertrophic and hyperkeratotic lesions, is variable, an effect attributable to a supposed lack of ALA penetration. A detailed and depth-related profile of spatial ALA permeation in AK following drug administration would lead to a greater understanding of concentrations achievable before protoporphyrin IX biosynthesis and subsequent PDT.
| Original language | English |
|---|---|
| Pages (from-to) | 183-190 |
| Number of pages | 8 |
| Journal | PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE |
| Volume | 24 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Aug 2008 |
ASJC Scopus subject areas
- Immunology
- Dermatology
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McLoone, N., Donnelly, R., Walsh, M., Dolan, O. M., McLoone, S., McKenna, K., & McCarron, P. A. (2008). Aminolaevulinic acid diffusion characteristics in 'in vitro' normal human skin and actinic keratosis: implications for topical photodynamic therapy. PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE, 24(4), 183-190. https://doi.org/10.1111/j.1600-0781.2008.00358.x