Amphiphilic block copolymer-based photonic platform towards efficient protein detection

Afroditi Petropoulou, Thomas J. Gibson, Efrosyni Themistou, Stergios Pispas, Christos Riziotis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The development of a low complexity fiber optic based protein sensor by functionalizing the surface of silica optical fibers using block copolymers having both hydrophobic poly(methyl methacrylate) (PMMA) and hydrophilic poly[2- (dimethylamino)ethyl methacrylate] (PDMAEMA) blocks is presented here. The amphiphilic thiol-functionalized PMMA117-b-P(DMAEMA17-st-TEMA2) and vinyl-sulfone PMMA117-b-P(DMAEMA17-st-VSTEMA2) block copolymers designed and synthesized in this work contain a cationic hydrophilic PDMAEMA block that can electrostatically bind selected oppositely charged proteins and also appropriate functional groups for reversible or non-reversible protein binding, respectively, leading to a refractive index change of the overlayer and hence, enabling the sensing. The developed PMMA117-b-PDMAEMA16-based platform has been evaluated for bovine serum albumin (BSA) sensing, exhibiting linear response to detected BSA concentrations.

Original languageEnglish
Title of host publicationAdvanced Sensor Systems and Applications VII: Proceedings
EditorsRene Landgraf, Tiegen Liu, Shibin Jiang
PublisherSPIE
ISBN (Electronic)9781510604698
DOIs
Publication statusPublished - 14 Nov 2016
EventAdvanced Sensor Systems and Applications VII - Beijing, China
Duration: 12 Oct 201614 Oct 2016

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume10025
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

ConferenceAdvanced Sensor Systems and Applications VII
CountryChina
CityBeijing
Period12/10/201614/10/2016

Keywords

  • Biosensors
  • Block copolymers
  • Fibers sensors
  • Protein

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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