@inproceedings{d431188e1bab487bbe2fb7f33c7ef4bb,
title = "Amphiphilic block copolymer-based photonic platform towards efficient protein detection",
abstract = "The development of a low complexity fiber optic based protein sensor by functionalizing the surface of silica optical fibers using block copolymers having both hydrophobic poly(methyl methacrylate) (PMMA) and hydrophilic poly[2- (dimethylamino)ethyl methacrylate] (PDMAEMA) blocks is presented here. The amphiphilic thiol-functionalized PMMA117-b-P(DMAEMA17-st-TEMA2) and vinyl-sulfone PMMA117-b-P(DMAEMA17-st-VSTEMA2) block copolymers designed and synthesized in this work contain a cationic hydrophilic PDMAEMA block that can electrostatically bind selected oppositely charged proteins and also appropriate functional groups for reversible or non-reversible protein binding, respectively, leading to a refractive index change of the overlayer and hence, enabling the sensing. The developed PMMA117-b-PDMAEMA16-based platform has been evaluated for bovine serum albumin (BSA) sensing, exhibiting linear response to detected BSA concentrations.",
keywords = "Biosensors, Block copolymers, Fibers sensors, Protein",
author = "Afroditi Petropoulou and Gibson, {Thomas J.} and Efrosyni Themistou and Stergios Pispas and Christos Riziotis",
year = "2016",
month = nov,
day = "14",
doi = "10.1117/12.2246506",
language = "English",
series = "Proceedings of SPIE - The International Society for Optical Engineering",
publisher = "SPIE",
editor = "Rene Landgraf and Tiegen Liu and Shibin Jiang",
booktitle = "Advanced Sensor Systems and Applications VII: Proceedings",
address = "United States",
note = "Advanced Sensor Systems and Applications VII ; Conference date: 12-10-2016 Through 14-10-2016",
}