An electroactive oligo‐EDOT platform for neural tissue engineering

Kaja I. Ritzau‐Reid; Christopher D. Spicer; Amy Gelmi; Christopher L. Grigsby; Jr James F. Ponder; Victoria Bemmer; Adam Creamer; Ramon Vilar; Andrea Serio; Molly M. Stevens

doi:10.1002/adfm.202003710

An electroactive oligo‐EDOT platform for neural tissue engineering

Kaja I. Ritzau‐Reid, Christopher D. Spicer, Amy Gelmi, Christopher L. Grigsby, Jr James F. Ponder, Victoria Bemmer, Adam Creamer, Ramon Vilar, Andrea Serio, Molly M. Stevens

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Abstract

The unique electrochemical properties of the conductive polymer poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) make it an attractive material for use in neural tissue engineering applications. However, inadequate mechanical properties, and difficulties in processing and lack of biodegradability have hindered progress in this field. Here, the functionality of PEDOT:PSS for neural tissue engineering is improved by incorporating 3,4-ethylenedioxythiophene (EDOT) oligomers, synthesized using a novel end-capping strategy, into block co-polymers. By exploiting end-functionalized oligoEDOT constructs as macroinitiators for the polymerization of poly(caprolactone), a block co-polymer is produced that is electroactive, processable, and bio-compatible. By combining these properties, electroactive fibrous mats are produced for neuronal culture via solution electrospinning and melt electrospinning writing. Importantly, it is also shown that neurite length and branching of neural stem cells can be enhanced on the materials under electrical stimulation, demonstrating the promise of these scaffolds for neural tissue engineering.

Original language	English
Article number	2003710
Number of pages	11
Journal	Advanced Functional Materials
Volume	30
DOIs	https://doi.org/10.1002/adfm.202003710
Publication status	Published - Oct 2020
Externally published	Yes

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10.1002/adfm.202003710Licence: CC BY

An electroactive oligo-EDOT platform for neural tissue engineering
© 2020 The Authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 4.96 MBLicence: CC BY

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title = "An electroactive oligo‐EDOT platform for neural tissue engineering",

abstract = "The unique electrochemical properties of the conductive polymer poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) make it an attractive material for use in neural tissue engineering applications. However, inadequate mechanical properties, and difficulties in processing and lack of biodegradability have hindered progress in this field. Here, the functionality of PEDOT:PSS for neural tissue engineering is improved by incorporating 3,4-ethylenedioxythiophene (EDOT) oligomers, synthesized using a novel end-capping strategy, into block co-polymers. By exploiting end-functionalized oligoEDOT constructs as macroinitiators for the polymerization of poly(caprolactone), a block co-polymer is produced that is electroactive, processable, and bio-compatible. By combining these properties, electroactive fibrous mats are produced for neuronal culture via solution electrospinning and melt electrospinning writing. Importantly, it is also shown that neurite length and branching of neural stem cells can be enhanced on the materials under electrical stimulation, demonstrating the promise of these scaffolds for neural tissue engineering.",

author = "Ritzau‐Reid, {Kaja I.} and Spicer, {Christopher D.} and Amy Gelmi and Grigsby, {Christopher L.} and {James F. Ponder}, Jr and Victoria Bemmer and Adam Creamer and Ramon Vilar and Andrea Serio and Stevens, {Molly M.}",

year = "2020",

month = oct,

doi = "10.1002/adfm.202003710",

language = "English",

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AU - Ritzau‐Reid, Kaja I.

AU - Spicer, Christopher D.

AU - Gelmi, Amy

AU - Grigsby, Christopher L.

AU - James F. Ponder, Jr

AU - Bemmer, Victoria

AU - Creamer, Adam

AU - Vilar, Ramon

AU - Serio, Andrea

AU - Stevens, Molly M.

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N2 - The unique electrochemical properties of the conductive polymer poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) make it an attractive material for use in neural tissue engineering applications. However, inadequate mechanical properties, and difficulties in processing and lack of biodegradability have hindered progress in this field. Here, the functionality of PEDOT:PSS for neural tissue engineering is improved by incorporating 3,4-ethylenedioxythiophene (EDOT) oligomers, synthesized using a novel end-capping strategy, into block co-polymers. By exploiting end-functionalized oligoEDOT constructs as macroinitiators for the polymerization of poly(caprolactone), a block co-polymer is produced that is electroactive, processable, and bio-compatible. By combining these properties, electroactive fibrous mats are produced for neuronal culture via solution electrospinning and melt electrospinning writing. Importantly, it is also shown that neurite length and branching of neural stem cells can be enhanced on the materials under electrical stimulation, demonstrating the promise of these scaffolds for neural tissue engineering.

AB - The unique electrochemical properties of the conductive polymer poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) make it an attractive material for use in neural tissue engineering applications. However, inadequate mechanical properties, and difficulties in processing and lack of biodegradability have hindered progress in this field. Here, the functionality of PEDOT:PSS for neural tissue engineering is improved by incorporating 3,4-ethylenedioxythiophene (EDOT) oligomers, synthesized using a novel end-capping strategy, into block co-polymers. By exploiting end-functionalized oligoEDOT constructs as macroinitiators for the polymerization of poly(caprolactone), a block co-polymer is produced that is electroactive, processable, and bio-compatible. By combining these properties, electroactive fibrous mats are produced for neuronal culture via solution electrospinning and melt electrospinning writing. Importantly, it is also shown that neurite length and branching of neural stem cells can be enhanced on the materials under electrical stimulation, demonstrating the promise of these scaffolds for neural tissue engineering.

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VL - 30

JO - Advanced Functional Materials

JF - Advanced Functional Materials

M1 - 2003710

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An electroactive oligo‐EDOT platform for neural tissue engineering

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