An examination of the thermorheological and drug release properties of zinc tetraphenylporphyrin-containing thermoresponsive hydrogels, designed as light activated antimicrobial implants

David Jones, Victoria Lorimer, Gavin Andrews, Colin McCoy, Sean Gorman

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

This study describes the thermorheological, mechanical and drug release properties of novel, light-activated antimicrobial implants. Hydrogels, based on N-isopropylacrylamide (NIPAA) and hydroxyethyl methacryl ate (HEMA) and either devoid of or containing zinc tetraphenylporphyrin, were prepared by free radical polymerisation and characterised using oscillatory rheometry and texture profile analysis. Drug release was studied at both 20 and 37 degrees C. Hydrogels containing NIPAA exhibited a sol-gel temperature (Tin), which increased as the proportion of HEMA increased and was
Original languageEnglish
Pages (from-to)990-999
Number of pages10
JournalChemical Engineering Science
Volume62
Issue number4
DOIs
Publication statusPublished - Feb 2007

ASJC Scopus subject areas

  • Chemical Engineering(all)

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