An experimental study of quinine blindness

T. A. Buchanan; R. W. Lyness; A. D. Collins; T. A. Gardiner; D. B. Archer

An experimental study of quinine blindness

T. A. Buchanan, R. W. Lyness, A. D. Collins, T. A. Gardiner, D. B. Archer

Research output: Contribution to journal › Article › peer-review

Abstract

An experimental model of quinine induced blindness is presented. Electrophysiological, angiographical and morphological examinations were made. The occurrence of blindness and any recovery from blindness was dependent upon the dose of quinine taken. As no evidence of acute retinal ischaemia was found it is concluded that quinine is retinotoxic.

Original language	Undefined/Unknown
Pages (from-to)	522-524
Number of pages	3
Journal	Eye
Volume	1 ( Pt 4)
Issue number	Pt 4
Publication status	Published - 1987

Bibliographical note

LR: 20091103; JID: 8703986; 130-95-0 (Quinine); ppublish

Keywords

Animals
Blindness/chemically induced/physiopathology
Cats
Disease Models, Animal
Dose-Response Relationship, Drug
Electroretinography
Evoked Potentials, Visual
Female
Male
Microscopy, Electron
Quinine/toxicity
Retina/drug effects/ultrastructure
Retinal Diseases/pathology

Cite this

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title = "An experimental study of quinine blindness",

abstract = "An experimental model of quinine induced blindness is presented. Electrophysiological, angiographical and morphological examinations were made. The occurrence of blindness and any recovery from blindness was dependent upon the dose of quinine taken. As no evidence of acute retinal ischaemia was found it is concluded that quinine is retinotoxic.",

keywords = "Animals, Blindness/chemically induced/physiopathology, Cats, Disease Models, Animal, Dose-Response Relationship, Drug, Electroretinography, Evoked Potentials, Visual, Female, Male, Microscopy, Electron, Quinine/toxicity, Retina/drug effects/ultrastructure, Retinal Diseases/pathology",

author = "Buchanan, {T. A.} and Lyness, {R. W.} and Collins, {A. D.} and Gardiner, {T. A.} and Archer, {D. B.}",

note = "LR: 20091103; JID: 8703986; 130-95-0 (Quinine); ppublish",

year = "1987",

language = "Undefined/Unknown",

volume = "1 ( Pt 4)",

pages = "522--524",

journal = "Eye",

issn = "0950-222X",

publisher = "Springer Nature",

number = "Pt 4",

}

TY - JOUR

T1 - An experimental study of quinine blindness

AU - Buchanan, T. A.

AU - Lyness, R. W.

AU - Collins, A. D.

AU - Gardiner, T. A.

AU - Archer, D. B.

N1 - LR: 20091103; JID: 8703986; 130-95-0 (Quinine); ppublish

PY - 1987

Y1 - 1987

N2 - An experimental model of quinine induced blindness is presented. Electrophysiological, angiographical and morphological examinations were made. The occurrence of blindness and any recovery from blindness was dependent upon the dose of quinine taken. As no evidence of acute retinal ischaemia was found it is concluded that quinine is retinotoxic.

AB - An experimental model of quinine induced blindness is presented. Electrophysiological, angiographical and morphological examinations were made. The occurrence of blindness and any recovery from blindness was dependent upon the dose of quinine taken. As no evidence of acute retinal ischaemia was found it is concluded that quinine is retinotoxic.

KW - Animals

KW - Blindness/chemically induced/physiopathology

KW - Cats

KW - Disease Models, Animal

KW - Dose-Response Relationship, Drug

KW - Electroretinography

KW - Evoked Potentials, Visual

KW - Female

KW - Male

KW - Microscopy, Electron

KW - Quinine/toxicity

KW - Retina/drug effects/ultrastructure

KW - Retinal Diseases/pathology

M3 - Article

SN - 0950-222X

VL - 1 ( Pt 4)

SP - 522

EP - 524

JO - Eye

JF - Eye

IS - Pt 4

ER -