An eye on RNAi in nematode parasites

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)

Abstract

RNA interference (RNAi) has revolutionised approaches to gene function determination. From a parasitology perspective, gene function studies have the added dimension of providing validation data, increasingly deemed essential to the initial phases of drug target selection, pre-screen development. Notionally advantageous to those working on nematode parasites is the fact that Caenorhabditis elegans research spawned RNAi discovery and continues to seed our understanding of its fundamentals. Unfortunately, RNAi data for nematode parasites illustrate variable and inconsistent susceptibilities which undermine confidence and exploitation. Now well-ensconced in an era of nematode parasite genomics, we can begin to unscramble this variation.
Original languageEnglish
Pages (from-to)505-513
Number of pages9
JournalTrends in Parasitology
Volume27
Issue number11
DOIs
Publication statusPublished - Nov 2011

ASJC Scopus subject areas

  • Infectious Diseases
  • Parasitology

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