An infection-responsive approach to reduce bacterial adhesion in urinary biomaterials

Colin P. McCoy, Nicola J. Irwin, Christopher Brady, David S. Jones, Louise Carson, Gavin P. Andrews, Sean P. Gorman

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)
334 Downloads (Pure)

Abstract

Infection is an inevitable consequence of chronic urinary catheterisation, with associated problems of recurrent catheter encrustation and blockage experienced by approximately 50% of all long-term catheterised patients. In this work we have exploited, for the first time, the reported pathogen-induced elevation of urine pH as a trigger for ‘intelligent’ antimicrobial release from novel hydrogel drug delivery systems of 2-hydroxyethyl methacrylate and vinyl-functionalised nalidixic acid derivatives, developed as candidate infection-resistant urinary catheter coatings. Demonstrating up to 20-fold faster rates of drug release at pH 10, representing infected urine pH, than at pH 7, and achieving reductions of up to 96.5% in in vitro bacterial adherence, our paradigm of pH-responsive drug delivery, which requires no external manipulation, therefore represents a promising development towards the prevention of catheter-associated urinary tract infections (CAUTIs) in vivo.
Original languageEnglish
Pages (from-to)2817–2822
Number of pages6
JournalMolecular Pharmaceutics
Volume13
Issue number8
Early online date30 Jun 2016
DOIs
Publication statusPublished - 2016

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