Objective: To understand the prevalence and pattern of comorbidities and multimorbidity in adults with severe asthma and their association with asthma-related outcomes.
Methods: This was a cross-sectional study using data from the International Severe Asthma Registry from 22 countries. Thirty comorbidities were identified and categorized a priori as either (1) potentially T2-related, (2) potentially oral corticosteroid (OCS)-related or (3) mimicking/aggravating asthma. The association between comorbidities and asthma-related outcomes was investigated using multivariable models adjusted for country, age at enrollment, and sex.Results: Of 11,821 patients, 69%, 67%, and 55% had ≥1 potentially T2-related, potentially OCSrelated, or mimicking/aggravating comorbidities, respectively; 57% had ≥3 comorbidities, and 33% had comorbidities in all three categories. Patients with allergic rhinitis (AR), nasal polyposis (NP), and chronic rhinosinusitis (CRS) experienced 1.12- (p=0.003), 1.16- (p(ORs: 1.37-1.57). Greater number of comorbidities was associated with worse outcome.
Conclusion: In a global study, comorbidity or multimorbidity is reported in most adults with severe asthma and is associated with poorer asthma-related outcomes.
|Journal||Annals of Allergy, Asthma and Immunology|
|Publication status||Accepted - 12 Aug 2023|
- Allergic rhinitis
- chronic obstructive pulmonary disease
- chronic rhinosinusitis
- diabetes, dyslipidemia
- gastroesophageal reflux disease
- nasal polys
- sleep apnea