Anatomy and physiology of the human eye: effects of mucopolysaccharidoses disease on structure and function - a review

Colin Willoughby, D. Ponzin, S. Ferrari, A. Lobo, K. Landau, Y. Omidi

Research output: Contribution to journalArticlepeer-review

81 Citations (Scopus)

Abstract

P>The current paper provides an overview of current knowledge on the structure and function of the eye. It describes in depth the different parts of the eye that are involved in the ocular manifestations seen in the mucopolysaccharidoses (MPS). The MPS are a group of rare inheritable lysosomal storage disorders characterized by the accumulation of glycosaminoglycans (GAGs) in cells and tissues all over the body, leading to widespread tissue and organ dysfunction. GAGs also tend to accumulate in several tissues of the eye, leading to various ocular manifestations affecting both the anterior (cornea, conjunctiva) and the posterior parts (retina, sclera, optic nerve) of the eye.
Original languageEnglish
Pages (from-to)2-11
Number of pages10
JournalClinical and Experimental Ophthalmology
Volume38
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Aug 2010

ASJC Scopus subject areas

  • Ophthalmology

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