Androgens and estrogens stimulate ribosome biogenesis in prostate and breast cancer cells in receptor dependent manner

Swagat Ray, Rebecca Johnston, David C Campbell, Shannen Nugent, Simon S McDade, David Waugh, Konstantin I Panov

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Ribosome biogenesis is a fundamental cellular process intimately linked to cell growth and proliferation, which is upregulated in most of cancers especially in aggressive cancers. In breast and prostate cancers steroid hormone receptor signalling is the principal stimulus for cancer growth and progression. Here we investigated the link between estrogen and androgen receptor signalling and the initial stage of ribosome biogenesis - transcription of rRNA genes. We have discovered that estrogen or androgen treatment can positively regulate rRNA synthesis in breast and prostate cancer cells respectively and that this effect is receptor dependent. This novel and interesting finding suggests a previously unidentified link between steroid hormone receptor signalling pathways and the regulation of ribosome biogenesis.
LanguageEnglish
Pages46-53
Number of pages8
JournalGene
Volume526
Issue number1
DOIs
Publication statusPublished - 19 Apr 2013

Fingerprint

Ribosomes
Androgens
Prostatic Neoplasms
Estrogens
Steroid Receptors
Breast Neoplasms
Hormones
Neoplasms
Androgen Receptors
Growth
rRNA Genes
Estrogen Receptors
Cell Proliferation

Bibliographical note

Copyright © 2013 Elsevier B.V. All rights reserved.

Cite this

Ray, Swagat ; Johnston, Rebecca ; Campbell, David C ; Nugent, Shannen ; McDade, Simon S ; Waugh, David ; Panov, Konstantin I. / Androgens and estrogens stimulate ribosome biogenesis in prostate and breast cancer cells in receptor dependent manner. In: Gene. 2013 ; Vol. 526, No. 1. pp. 46-53.
@article{84bfc6c8ce9c47a3a2c3d964d677f473,
title = "Androgens and estrogens stimulate ribosome biogenesis in prostate and breast cancer cells in receptor dependent manner",
abstract = "Ribosome biogenesis is a fundamental cellular process intimately linked to cell growth and proliferation, which is upregulated in most of cancers especially in aggressive cancers. In breast and prostate cancers steroid hormone receptor signalling is the principal stimulus for cancer growth and progression. Here we investigated the link between estrogen and androgen receptor signalling and the initial stage of ribosome biogenesis - transcription of rRNA genes. We have discovered that estrogen or androgen treatment can positively regulate rRNA synthesis in breast and prostate cancer cells respectively and that this effect is receptor dependent. This novel and interesting finding suggests a previously unidentified link between steroid hormone receptor signalling pathways and the regulation of ribosome biogenesis.",
author = "Swagat Ray and Rebecca Johnston and Campbell, {David C} and Shannen Nugent and McDade, {Simon S} and David Waugh and Panov, {Konstantin I}",
note = "Copyright {\circledC} 2013 Elsevier B.V. All rights reserved.",
year = "2013",
month = "4",
day = "19",
doi = "10.1016/j.gene.2013.04.018",
language = "English",
volume = "526",
pages = "46--53",
journal = "Gene",
issn = "0378-1119",
publisher = "Elsevier",
number = "1",

}

Androgens and estrogens stimulate ribosome biogenesis in prostate and breast cancer cells in receptor dependent manner. / Ray, Swagat; Johnston, Rebecca; Campbell, David C; Nugent, Shannen; McDade, Simon S; Waugh, David; Panov, Konstantin I.

In: Gene, Vol. 526, No. 1, 19.04.2013, p. 46-53.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Androgens and estrogens stimulate ribosome biogenesis in prostate and breast cancer cells in receptor dependent manner

AU - Ray, Swagat

AU - Johnston, Rebecca

AU - Campbell, David C

AU - Nugent, Shannen

AU - McDade, Simon S

AU - Waugh, David

AU - Panov, Konstantin I

N1 - Copyright © 2013 Elsevier B.V. All rights reserved.

PY - 2013/4/19

Y1 - 2013/4/19

N2 - Ribosome biogenesis is a fundamental cellular process intimately linked to cell growth and proliferation, which is upregulated in most of cancers especially in aggressive cancers. In breast and prostate cancers steroid hormone receptor signalling is the principal stimulus for cancer growth and progression. Here we investigated the link between estrogen and androgen receptor signalling and the initial stage of ribosome biogenesis - transcription of rRNA genes. We have discovered that estrogen or androgen treatment can positively regulate rRNA synthesis in breast and prostate cancer cells respectively and that this effect is receptor dependent. This novel and interesting finding suggests a previously unidentified link between steroid hormone receptor signalling pathways and the regulation of ribosome biogenesis.

AB - Ribosome biogenesis is a fundamental cellular process intimately linked to cell growth and proliferation, which is upregulated in most of cancers especially in aggressive cancers. In breast and prostate cancers steroid hormone receptor signalling is the principal stimulus for cancer growth and progression. Here we investigated the link between estrogen and androgen receptor signalling and the initial stage of ribosome biogenesis - transcription of rRNA genes. We have discovered that estrogen or androgen treatment can positively regulate rRNA synthesis in breast and prostate cancer cells respectively and that this effect is receptor dependent. This novel and interesting finding suggests a previously unidentified link between steroid hormone receptor signalling pathways and the regulation of ribosome biogenesis.

U2 - 10.1016/j.gene.2013.04.018

DO - 10.1016/j.gene.2013.04.018

M3 - Article

VL - 526

SP - 46

EP - 53

JO - Gene

T2 - Gene

JF - Gene

SN - 0378-1119

IS - 1

ER -