Animal models of diabetic retinopathy

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

13 Citations (Scopus)

Abstract

Diabetic retinopathy (DR) is a major cause of visual impairment worldwide. The precise pathogenesis of this diabetic complication remains ill-defined and this is reflected in the limited options for preventing development and progression of this disease. The value of animal models to understand and treat human disease is well recognised and this chapter focuses on the range of in vivo model systems that are available for studying DR. These models have been developed over many decades and utilised to aid our understanding of what causes DR, about how microvascular and neural lesions develop and to provide evidence for key cellular and molecular mechanisms that drive this pathology. A wide range of animal models of DR are currently available, each with advantages and disadvantages that need to be understood and evaluated for their scientific and clinical value. As transgenic and imaging technology improves, more models will be developed and they will continue to play a critical role in the development of new therapeutic approaches to DR by providing robust, preclinical evidence prior to clinical trial.
Original languageEnglish
Title of host publicationAnimal models of ophthalmic diseases
EditorsChi-Chao Chan
PublisherSpringer
Pages67-83
ISBN (Electronic)978-3-319-19434-9
ISBN (Print)978-3-319-19433-2
DOIs
Publication statusPublished - 2016

Publication series

NameEssentials in Ophthalmology
PublisherSpringer
ISSN (Print)1612-3212

Fingerprint

Diabetic Retinopathy
Animal Models
Vision Disorders
Diabetes Complications
Disease Progression
Clinical Trials
Pathology
Technology

Cite this

Chen, M., & Stitt, A. (2016). Animal models of diabetic retinopathy. In C-C. Chan (Ed.), Animal models of ophthalmic diseases (pp. 67-83). [Chapter 5] (Essentials in Ophthalmology). Springer. https://doi.org/10.1007/978-3-319-19434-9_5
Chen, Mei ; Stitt, Alan. / Animal models of diabetic retinopathy. Animal models of ophthalmic diseases. editor / Chi-Chao Chan. Springer, 2016. pp. 67-83 (Essentials in Ophthalmology).
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abstract = "Diabetic retinopathy (DR) is a major cause of visual impairment worldwide. The precise pathogenesis of this diabetic complication remains ill-defined and this is reflected in the limited options for preventing development and progression of this disease. The value of animal models to understand and treat human disease is well recognised and this chapter focuses on the range of in vivo model systems that are available for studying DR. These models have been developed over many decades and utilised to aid our understanding of what causes DR, about how microvascular and neural lesions develop and to provide evidence for key cellular and molecular mechanisms that drive this pathology. A wide range of animal models of DR are currently available, each with advantages and disadvantages that need to be understood and evaluated for their scientific and clinical value. As transgenic and imaging technology improves, more models will be developed and they will continue to play a critical role in the development of new therapeutic approaches to DR by providing robust, preclinical evidence prior to clinical trial.",
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Chen, M & Stitt, A 2016, Animal models of diabetic retinopathy. in C-C Chan (ed.), Animal models of ophthalmic diseases., Chapter 5, Essentials in Ophthalmology, Springer, pp. 67-83. https://doi.org/10.1007/978-3-319-19434-9_5

Animal models of diabetic retinopathy. / Chen, Mei; Stitt, Alan.

Animal models of ophthalmic diseases. ed. / Chi-Chao Chan. Springer, 2016. p. 67-83 Chapter 5 (Essentials in Ophthalmology).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

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AB - Diabetic retinopathy (DR) is a major cause of visual impairment worldwide. The precise pathogenesis of this diabetic complication remains ill-defined and this is reflected in the limited options for preventing development and progression of this disease. The value of animal models to understand and treat human disease is well recognised and this chapter focuses on the range of in vivo model systems that are available for studying DR. These models have been developed over many decades and utilised to aid our understanding of what causes DR, about how microvascular and neural lesions develop and to provide evidence for key cellular and molecular mechanisms that drive this pathology. A wide range of animal models of DR are currently available, each with advantages and disadvantages that need to be understood and evaluated for their scientific and clinical value. As transgenic and imaging technology improves, more models will be developed and they will continue to play a critical role in the development of new therapeutic approaches to DR by providing robust, preclinical evidence prior to clinical trial.

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BT - Animal models of ophthalmic diseases

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PB - Springer

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Chen M, Stitt A. Animal models of diabetic retinopathy. In Chan C-C, editor, Animal models of ophthalmic diseases. Springer. 2016. p. 67-83. Chapter 5. (Essentials in Ophthalmology). https://doi.org/10.1007/978-3-319-19434-9_5