Anthracene-modified oligonucleotides as fluorescent DNA mismatch sensors: discrimination between various base-pair mismatches

J.L.H.A. Duprey, D.M. Bassani, E.I. Hyde, C. Ludwig, A. Rodger, Joseph Vyle, J. Wilkie, Z.Y. Zhao, J.H.R. Tucker

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

A fluorescent anthracene-tagged DNA probe has been shown to respond to various DNA sequences by changes to its emission signal upon duplex formation. The fluorescence response for duplexes containing a single mismatch near the anthracene site has been found to be very sensitive to its composition, with the emission signal increasing for a CA mismatch and decreasing for CT and CC mismatches.
Original languageEnglish
Pages (from-to)273-277
Number of pages5
JournalSUPRAMOLECULAR CHEMISTRY
Volume23
Issue number3-4
DOIs
Publication statusPublished - Mar 2011

ASJC Scopus subject areas

  • Chemistry(all)

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