Anti-diabetic potential of selected Malaysian seaweeds

Yao Xian Chin, Phaik Eem Lim, Christine A. Maggs, Siew Moi Phang, Yusrizam Sharifuddin*, Brian D. Green

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

The emergence of type 2 diabetes mellitus (T2DM) as the pre-eminent global non-infectious disease has driven the search for new anti-diabetic strategies including utilising traditional food and herbs. In this investigation, we describe the anti-diabetic potential of six selected Malaysian seaweed species against recognised pharmacological targets. Specifically, we measured their ability to inhibit α-glucosidase and dipeptidyl-peptidase-4 (DPP-4) and also their ability to stimulate incretin hormone secretion in vitro. Crude water extracts of Halimeda macroloba, Padina sulcata, Sargassum binderi and Turbinaria conoides possessed potent inhibitory activities against α-glucosidase and DPP-4. The highest inhibitory activity against α-glucosidase was found in water extracts of the green seaweed species H. macroloba with an IC50value of 6.388 mg mL−1. Crude water extracts of the brown seaweeds studied namely P. sulcata, S. binderi and T. conoides, exhibited potent DPP-4 inhibition compared with the green seaweed H. macroloba. The brown seaweed also stimulates secretion of glucose-dependent insulinotrophic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) from pGIP neo STC-1 cells in vitro. H. macroloba stimulated GLP-1 secretion but not secretion of GIP.

Original languageEnglish
Pages (from-to)2137-2148
JournalJournal of Applied Phycology
Volume27
Issue number5
Early online date22 Nov 2014
DOIs
Publication statusPublished - Oct 2015

Keywords

  • Algae
  • Biotechnology
  • Diabetes
  • DPP-4
  • GIP
  • GLP
  • Seaweed
  • α-glucosidase

ASJC Scopus subject areas

  • Aquatic Science
  • Plant Science

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