Antibiotic Prescription Patterns in the Paediatric Primary Care Setting before and after the COVID-19 Pandemic in Italy: An Analysis Using the AWaRe Metrics

Elisa Barbieri*, Cecilia Liberati, Anna Cantarutti, Costanza Di Chiara, Angela Lupattelli, Michael Sharland, Carlo Giaquinto, Yingfen Hsia, Daniele Doná

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)
71 Downloads (Pure)

Abstract

The containment measures following COVID-19 pandemic drastically reduced airway infections, but they also limited the access of patients to healthcare services. We aimed to assess the antibiotic prescription patterns in the Italian paediatric primary care setting before and after the containment measures implementation. For this retrospective analysis, we used a population database, Pedianet, collecting data of patients aged 0−14 years enrolled with family paediatricians (FP) from March 2019 to March 2021. Antibiotic prescriptions were classified according to WHO AWaRe classification. An interrupted time series evaluating the impact of the containment measures implementation on the monthly antibiotic index, on the access to watch index, and on the amoxicillin to co-amoxiclav index stratified by diagnosis was performed. Overall, 121,304 antibiotic prescriptions were retrieved from 134 FP, for a total of 162,260 children. From March 2020, the antibiotic index dropped by more than 80% for respiratory infections. The Access to Watch trend did not change after the containment measures, reflecting the propensity to prescribe more broad-spectrum antibiotics for respiratory infections even during the pandemic. Similarly, co-amoxiclav was prescribed more often than amoxicillin alone for all the diagnoses, with a significant variation in the trend slope for upper respiratory tract infections prescriptions.
Original languageEnglish
Article numbere457
JournalAntibiotics
Volume11
Issue number4
Early online date29 Mar 2022
DOIs
Publication statusEarly online date - 29 Mar 2022

Keywords

  • antibiotics
  • AWaRe classification
  • COVID-19 pandemic

Fingerprint

Dive into the research topics of 'Antibiotic Prescription Patterns in the Paediatric Primary Care Setting before and after the COVID-19 Pandemic in Italy: An Analysis Using the AWaRe Metrics'. Together they form a unique fingerprint.

Cite this