TY - JOUR
T1 - Antibody responses to Helicobacter pylori and risk of developing colorectal cancer in a European cohort
AU - Butt, Julia
AU - Jenab, Mazda
AU - Pawlita, Michael
AU - Tjonneland, Anne
AU - Kyrø, Cecilie
AU - Boutron-Ruault, Marie-Christine
AU - Carbonnel, Franck
AU - Dong, Catherine
AU - Kaaks, Rudolf
AU - Kühn, Tilman
AU - Boeing, Heiner
AU - Schulze, Matthias B
AU - Trichopoulou, Antonia
AU - Karakatsani, Anna
AU - La Vecchia, Carlo
AU - Palli, Domenico
AU - Agnoli, Claudia
AU - Tumino, Rosario
AU - Sacerdote, Carlotta
AU - Panico, Salvatore
AU - Bueno-de-Mesquita, Bas
AU - Vermeulen, Roel
AU - Gram, Inger T
AU - Weiderpass, Elisabete
AU - Benjaminsen Borch, Kristin
AU - Quirós, J Ramón
AU - Agudo, Antonio
AU - Rodríguez-Barranco, Miguel
AU - Santiuste, Carmen
AU - Ardanaz, Eva
AU - Van Guelpen, Bethany
AU - Harlid, Sophia
AU - Imaz, Liher
AU - Perez-Cornago, Aurora
AU - Gunter, Marc J
AU - Zouiouich, Semi
AU - Park, Jin Young
AU - Riboli, Elio
AU - Cross, Amanda J
AU - Heath, Alicia K
AU - Waterboer, Tim
AU - Hughes, David J
N1 - Copyright ©2020, American Association for Cancer Research.
PY - 2020/4/24
Y1 - 2020/4/24
N2 - BACKGROUND: While Helicobacter pylori (H. pylori) is the major cause of gastric cancer, it has also been suggested to be involved in colorectal cancer (CRC) development. However, prospective studies addressing H. pylori and CRC are sparse and inconclusive. We assessed the association of antibody responses to H. pylori proteins with CRC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.METHODS: We applied H. pylori multiplex serology to measure antibody responses to 13 H. pylori proteins in pre-diagnostic serum samples from 485 CRC cases and 485 matched controls nested within the EPIC study. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multivariable conditional logistic regression to estimate the association of H. pylori overall and protein-specific sero-positivity with odds of developing CRC.RESULTS: Fifty-one percent of CRC cases were H. pylori sero-positive compared to 44% of controls resulting in an OR of 1.36 (95% CI: 1.00-1.85). Among the 13 individual H. pylori proteins, the association was driven mostly by sero-positivity to Helicobacter cysteine-rich protein C (HcpC) (OR: 1.66, 95% CI: 1.19-2.30) and Vacuolating cytotoxin A (VacA) (OR: 1.34, 95% CI: 0.99-1.82), the latter being non-statistically significant only in the fully adjusted model.CONCLUSION: In this prospective multi-center European study, antibody responses to H. pylori proteins, specifically HcpC and VacA, were associated with an increased risk of developing CRC.IMPACT: Biological mechanisms for a potential causal role of H. pylori in colorectal carcinogenesis need to be elucidated, and subsequently whether H. pylori eradication may decrease CRC incidence.
AB - BACKGROUND: While Helicobacter pylori (H. pylori) is the major cause of gastric cancer, it has also been suggested to be involved in colorectal cancer (CRC) development. However, prospective studies addressing H. pylori and CRC are sparse and inconclusive. We assessed the association of antibody responses to H. pylori proteins with CRC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.METHODS: We applied H. pylori multiplex serology to measure antibody responses to 13 H. pylori proteins in pre-diagnostic serum samples from 485 CRC cases and 485 matched controls nested within the EPIC study. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multivariable conditional logistic regression to estimate the association of H. pylori overall and protein-specific sero-positivity with odds of developing CRC.RESULTS: Fifty-one percent of CRC cases were H. pylori sero-positive compared to 44% of controls resulting in an OR of 1.36 (95% CI: 1.00-1.85). Among the 13 individual H. pylori proteins, the association was driven mostly by sero-positivity to Helicobacter cysteine-rich protein C (HcpC) (OR: 1.66, 95% CI: 1.19-2.30) and Vacuolating cytotoxin A (VacA) (OR: 1.34, 95% CI: 0.99-1.82), the latter being non-statistically significant only in the fully adjusted model.CONCLUSION: In this prospective multi-center European study, antibody responses to H. pylori proteins, specifically HcpC and VacA, were associated with an increased risk of developing CRC.IMPACT: Biological mechanisms for a potential causal role of H. pylori in colorectal carcinogenesis need to be elucidated, and subsequently whether H. pylori eradication may decrease CRC incidence.
U2 - 10.1158/1055-9965.EPI-19-1545
DO - 10.1158/1055-9965.EPI-19-1545
M3 - Article
C2 - 32332031
JO - Cancer Epidemiology Biomarkers & Prevention
JF - Cancer Epidemiology Biomarkers & Prevention
SN - 1055-9965
ER -