Antibody Signatures Reflect Different Disease Pathologies in Patients With Schistosomiasis Due to Schistosoma japonicum

Patrick Driguez, Yuesheng Li, Soraya Gaze, Mark S Pearson, Rie Nakajima, Angela Trieu, Denise L Doolan, Philip L Felgner, Xunya Hou, Fernanda C Cardoso, Algis Jasinskas, Geoffrey N Gobert, Alex Loukas, Donald P McManus

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Infection with Schistosoma japonicum causes high levels of pathology that is predominantly determined by the cellular and humoral response of the host. However, the specific antibody response that arises during the development of disease is largely undescribed in Asian schistosomiasis-endemic populations. A schistosome protein microarray was used to compare the antibody profiles of subjects with acute infection, with early or advanced disease associated with severe pathology, with chronic infection, and subjects exposed but stool negative for S. japonicum eggs to the antibody profiles of nonexposed controls. Twenty-five immunodominant antigens were identified, including vaccine candidates, tetraspanin-related proteins, transporter molecules, and unannotated proteins. Additionally, individuals with severe pathology had a limited specific antibody response, suggesting that individuals with mild disease may use a broad and strong antibody response, particularly against surface-exposed proteins, to control pathology and/or infection. Our study has identified specific antigens that can discriminate between S. japonicum-exposed groups with different pathologies and may also allow the host to control disease pathology and provide resistance to parasite infection.

Original languageEnglish
Pages (from-to)122-30
Number of pages9
JournalThe Journal of Infectious Diseases
Issue number1
Early online date06 Jul 2015
Publication statusPublished - 2016
Event13th International Congress of Parasitology - Mexico City, Mexico
Duration: 10 Aug 201415 Aug 2014


  • Animals
  • Antibodies, Helminth
  • Antigens, Helminth
  • Cluster Analysis
  • Cohort Studies
  • Helminth Proteins
  • Humans
  • Protein Array Analysis
  • Schistosoma japonicum
  • Schistosomiasis


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