Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites

Ikhlas El Karim, Gerard Linden, D.F. Orr, Fionnuala Lundy

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Many neuropeptides are similar in size, amino acid composition and charge to antimicrobial peptides. This study aimed to determine whether the neuropeptides substance P (SP), neurokinin A (NKA), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY) and vasoactive intestinal polypeptide (VIP), displayed antimicrobial activity against Streptococcus mutans, Lactobacillus acidophilus, Enterococcus faecalis, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans. SP, NPY, VIP and CGRP displayed variable degrees of antimicrobial activity against all the pathogens tested with the exception of S. aureus. These antimicrobial activities add a further dimension to the immunomodulatory roles for neuropeptides in the inflammatory and immune responses. (c) 2008 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)11-16
Number of pages6
JournalJournal of Neuroimmunology
Volume200
Issue number1-2
DOIs
Publication statusPublished - 30 Aug 2008

Keywords

  • Anti-Infective Agents
  • Anticoagulants
  • Bacteria
  • Escherichia coli
  • Gastrointestinal Tract
  • Heparin
  • Humans
  • Microbial Sensitivity Tests
  • Mouth
  • Neuropeptides
  • Respiratory System
  • Skin
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
  • Tetrazolium Salts
  • Thiazoles

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