Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites

Ikhlas A.. El Karim; Gerard J. Linden; David F. Orr; Fionnuala T. Lundy

doi:10.1016/j.jneuroim.2008.05.014

Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites

Ikhlas A.. El Karim^*, Gerard J. Linden, David F. Orr, Fionnuala T. Lundy

^*Corresponding author for this work

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

151 Citations (Scopus)

Abstract

Many neuropeptides are similar in size, amino acid composition and charge to antimicrobial peptides. This study aimed to determine whether the neuropeptides substance P (SP), neurokinin A (NKA), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY) and vasoactive intestinal polypeptide (VIP), displayed antimicrobial activity against Streptococcus mutans, Lactobacillus acidophilus, Enterococcus faecalis, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans. SP, NPY, VIP and CGRP displayed variable degrees of antimicrobial activity against all the pathogens tested with the exception of S. aureus. These antimicrobial activities add a further dimension to the immunomodulatory roles for neuropeptides in the inflammatory and immune responses.

Original language	English
Pages (from-to)	11-16
Journal	Journal of Neuroimmunology
Volume	200
Issue number	1-2
Early online date	07 Jul 2008
DOIs	https://doi.org/10.1016/j.jneuroim.2008.05.014
Publication status	Published - 30 Aug 2008

Keywords

Anti-Infective Agents
Anticoagulants
Bacteria
Escherichia coli
Gastrointestinal Tract
Heparin
Humans
Microbial Sensitivity Tests
Mouth
Neuropeptides
Respiratory System
Skin
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Tetrazolium Salts
Thiazoles

Access to Document

10.1016/j.jneuroim.2008.05.014Licence: Unspecified

Cite this

@article{a6c890bde3d7478088f098821797c391,

title = "Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites",

abstract = "Many neuropeptides are similar in size, amino acid composition and charge to antimicrobial peptides. This study aimed to determine whether the neuropeptides substance P (SP), neurokinin A (NKA), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY) and vasoactive intestinal polypeptide (VIP), displayed antimicrobial activity against Streptococcus mutans, Lactobacillus acidophilus, Enterococcus faecalis, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans. SP, NPY, VIP and CGRP displayed variable degrees of antimicrobial activity against all the pathogens tested with the exception of S. aureus. These antimicrobial activities add a further dimension to the immunomodulatory roles for neuropeptides in the inflammatory and immune responses.",

keywords = "Anti-Infective Agents, Anticoagulants, Bacteria, Escherichia coli, Gastrointestinal Tract, Heparin, Humans, Microbial Sensitivity Tests, Mouth, Neuropeptides, Respiratory System, Skin, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Tetrazolium Salts, Thiazoles",

author = "{El Karim}, {Ikhlas A..} and Linden, {Gerard J.} and Orr, {David F.} and Lundy, {Fionnuala T.}",

year = "2008",

month = aug,

day = "30",

doi = "10.1016/j.jneuroim.2008.05.014",

language = "English",

volume = "200",

pages = "11--16",

journal = "Journal of Neuroimmunology",

issn = "1872-8421",

publisher = "Elsevier B.V.",

number = "1-2",

}

TY - JOUR

T1 - Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites

AU - El Karim, Ikhlas A..

AU - Linden, Gerard J.

AU - Orr, David F.

AU - Lundy, Fionnuala T.

PY - 2008/8/30

Y1 - 2008/8/30

N2 - Many neuropeptides are similar in size, amino acid composition and charge to antimicrobial peptides. This study aimed to determine whether the neuropeptides substance P (SP), neurokinin A (NKA), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY) and vasoactive intestinal polypeptide (VIP), displayed antimicrobial activity against Streptococcus mutans, Lactobacillus acidophilus, Enterococcus faecalis, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans. SP, NPY, VIP and CGRP displayed variable degrees of antimicrobial activity against all the pathogens tested with the exception of S. aureus. These antimicrobial activities add a further dimension to the immunomodulatory roles for neuropeptides in the inflammatory and immune responses.

AB - Many neuropeptides are similar in size, amino acid composition and charge to antimicrobial peptides. This study aimed to determine whether the neuropeptides substance P (SP), neurokinin A (NKA), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY) and vasoactive intestinal polypeptide (VIP), displayed antimicrobial activity against Streptococcus mutans, Lactobacillus acidophilus, Enterococcus faecalis, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans. SP, NPY, VIP and CGRP displayed variable degrees of antimicrobial activity against all the pathogens tested with the exception of S. aureus. These antimicrobial activities add a further dimension to the immunomodulatory roles for neuropeptides in the inflammatory and immune responses.

KW - Anti-Infective Agents

KW - Anticoagulants

KW - Bacteria

KW - Escherichia coli

KW - Gastrointestinal Tract

KW - Heparin

KW - Humans

KW - Microbial Sensitivity Tests

KW - Mouth

KW - Neuropeptides

KW - Respiratory System

KW - Skin

KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

KW - Tetrazolium Salts

KW - Thiazoles

U2 - 10.1016/j.jneuroim.2008.05.014

DO - 10.1016/j.jneuroim.2008.05.014

M3 - Article

C2 - 18603306

SN - 1872-8421

VL - 200

SP - 11

EP - 16

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites

Abstract

Keywords

Access to Document

Fingerprint

Cite this