Antimicrobial activity of short, synthetic cationic lipopeptides.

Martin McLaughlin, Christopher Shaw, Sean Gorman, Brendan Gilmore, Garry Laverty

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

The increasing emergence of multidrug-resistant micro-organisms presents one of the greatest challenges in the clinical management of infectious diseases. Therefore, novel antimicrobial agents are urgently required to address this issue. In this report, we describe the solid phase synthesis, characterization, microbiological and toxicological evaluation of a library of ultrashort cationic antimicrobial lipopeptides based on the previously described tetrapeptide amide H-Orn-Orn-Trp-Trp-NH2 conjugated with saturated fatty acids which have inherent antimicrobial activity. The microbiological activity of these ultrashort cationic lipopeptides, which exhibit excellent, broad-spectrum antimicrobial activity against a number of clinically important pathogenic bacteria and fungi, including multidrug resistant micro-organisms in both planktonic and sessile (biofilm) cultures is reported.
Original languageEnglish
Pages (from-to)563-569
Number of pages7
JournalChemical Biology & Drug Design
Volume75(6)
Issue number6
DOIs
Publication statusPublished - Jun 2010

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine

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