Antimicrobial cationic surfactant-loaded hydrogel coatings in preventing medical device-associated infections

Xiao Teng; Caoimhe G Clerkin; Colin P McCoy

doi:10.5920/bjpharm.1078

Antimicrobial cationic surfactant-loaded hydrogel coatings in preventing medical device-associated infections

Xiao Teng, Caoimhe G Clerkin, Colin P McCoy

School of Pharmacy

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Abstract

Hydrogels described herein were developedas anti-microbial coating materials. Three different hydrogels, p(HEMA), p(85%HEMA-co-15% MMA) and p(85% HEMA-co-15% MAA) were loaded with twocationic surfactant, BAK and DDAB, respectively. DDAB owned better effectivity thanBAK in killing S. aureus and E. coli. Compared to unmodifiedp(HEMA), all drug-loaded samples exhibited significant anti-adherence abilityagainst E. coli, but on surfaces of all DDAB-loaded hydrogels, bacteriawere below limit of detection, so DDAB was more effective than BAK inconferring anti-adherent properties.

Original language	English
Article number	1078
Journal	British Journal of Pharmacy
Volume	7
Issue number	2
DOIs	https://doi.org/10.5920/bjpharm.1078
Publication status	Published - 04 Nov 2022
Event	13th Academy of Pharmaceutical Sciences PharmSci International Conference 2022 - Belfast, United Kingdom Duration: 07 Sept 2022 → 09 Sept 2022 https://www.apsgb.co.uk/event/pharmsci-international-conference-belfast/

Keywords

Management Science and Operations Research
Mechanical Engineering
Energy Engineering and Power Technology

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10.5920/bjpharm.1078Licence: CC BY

Antimicrobial cationic surfactant-loaded hydrogel coatings in preventing medical device-associated infections
Copyright 2022 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 394 KBLicence: CC BY

Cite this

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title = "Antimicrobial cationic surfactant-loaded hydrogel coatings in preventing medical device-associated infections",

abstract = "Hydrogels described herein were developedas anti-microbial coating materials. Three different hydrogels, p(HEMA), p(85%HEMA-co-15% MMA) and p(85% HEMA-co-15% MAA) were loaded with twocationic surfactant, BAK and DDAB, respectively. DDAB owned better effectivity thanBAK in killing S. aureus and E. coli. Compared to unmodifiedp(HEMA), all drug-loaded samples exhibited significant anti-adherence abilityagainst E. coli, but on surfaces of all DDAB-loaded hydrogels, bacteriawere below limit of detection, so DDAB was more effective than BAK inconferring anti-adherent properties.",

keywords = "Management Science and Operations Research, Mechanical Engineering, Energy Engineering and Power Technology",

author = "Xiao Teng and Clerkin, {Caoimhe G} and McCoy, {Colin P}",

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Y1 - 2022/11/4

N2 - Hydrogels described herein were developedas anti-microbial coating materials. Three different hydrogels, p(HEMA), p(85%HEMA-co-15% MMA) and p(85% HEMA-co-15% MAA) were loaded with twocationic surfactant, BAK and DDAB, respectively. DDAB owned better effectivity thanBAK in killing S. aureus and E. coli. Compared to unmodifiedp(HEMA), all drug-loaded samples exhibited significant anti-adherence abilityagainst E. coli, but on surfaces of all DDAB-loaded hydrogels, bacteriawere below limit of detection, so DDAB was more effective than BAK inconferring anti-adherent properties.

AB - Hydrogels described herein were developedas anti-microbial coating materials. Three different hydrogels, p(HEMA), p(85%HEMA-co-15% MMA) and p(85% HEMA-co-15% MAA) were loaded with twocationic surfactant, BAK and DDAB, respectively. DDAB owned better effectivity thanBAK in killing S. aureus and E. coli. Compared to unmodifiedp(HEMA), all drug-loaded samples exhibited significant anti-adherence abilityagainst E. coli, but on surfaces of all DDAB-loaded hydrogels, bacteriawere below limit of detection, so DDAB was more effective than BAK inconferring anti-adherent properties.

KW - Management Science and Operations Research

KW - Mechanical Engineering

KW - Energy Engineering and Power Technology

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Antimicrobial cationic surfactant-loaded hydrogel coatings in preventing medical device-associated infections

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Keywords

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