Antioxidants in health and disease

Research output: Contribution to journalArticlepeer-review

1151 Citations (Scopus)

Abstract

Free radical production occurs continuously in all cells as part of normal cellular function. However, excess free radical production originating from endogenous or exogenous sources might play a role in many diseases. Antioxidants prevent free radical induced tissue damage by preventing the formation of radicals, scavenging them, or by promoting their decomposition. This article reviews the basic chemistry of free radical formation in the body, the consequences of free radical induced tissue damage, and the function of antioxidant defence systems, with particular reference to the development of atherosclerosis.
Original languageEnglish
Pages (from-to)176-186
Number of pages11
JournalJournal of Clinical Pathology
Volume54
Issue number3
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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