Apolipoprotein E polymorphism and serum concentration in Alzheimer's disease in nine European centres: the ApoEurope study. ApoEurope group

G Siest; P Bertrand; B Qin; B Herbeth; J M Serot; L Masana; J Ribalta; A P Passmore; A Evans; M Ferrari; M Franceschi; J Shepherd; M Cuchel; U Beisiegel; K Zuchowsky; A S Rukavina; J Sertic; M Stojanov; V Kostic; A Mitrevski; V Petrova; C Sass; A Merched; J T Salonen; L Tiret; S Visvikis

doi:10.1515/CCLM.2000.102

Apolipoprotein E polymorphism and serum concentration in Alzheimer's disease in nine European centres: the ApoEurope study. ApoEurope group

G Siest, P Bertrand, B Qin, B Herbeth, J M Serot, L Masana, J Ribalta, A P Passmore, A Evans, M Ferrari, M Franceschi, J Shepherd, M Cuchel, U Beisiegel, K Zuchowsky, A S Rukavina, J Sertic, M Stojanov, V Kostic, A MitrevskiV Petrova, C Sass, A Merched, J T Salonen, L Tiret, S Visvikis

Research output: Contribution to journal › Article › peer-review

73 Citations (Scopus)

Abstract

As part of the ApoEurope Project, apolipoprotein E (apo E) common polymorphism and serum concentration were determined in 489 Alzheimer's disease patients and 429 controls. Patients and controls were recruited through nine centres in eight European countries. Age, sex ratios and education levels of both case and control populations were similar, although discrete differences appeared between centres. The prevalence of the epsilon4 allele was higher in Alzheimer's disease than in controls (increased by 140%), while serum apo E concentration was lower by 11.2% (p

Original language	English
Pages (from-to)	721-30
Number of pages	10
Journal	Clinical chemistry and laboratory medicine : CCLM / FESCC
Volume	38
Issue number	8
DOIs	https://doi.org/10.1515/CCLM.2000.102
Publication status	Published - 2000

Access to Document

10.1515/CCLM.2000.102

Cite this

Siest, G., Bertrand, P., Qin, B., Herbeth, B., Serot, J. M., Masana, L., Ribalta, J., Passmore, A. P., Evans, A., Ferrari, M., Franceschi, M., Shepherd, J., Cuchel, M., Beisiegel, U., Zuchowsky, K., Rukavina, A. S., Sertic, J., Stojanov, M., Kostic, V., ... Visvikis, S. (2000). Apolipoprotein E polymorphism and serum concentration in Alzheimer's disease in nine European centres: the ApoEurope study. ApoEurope group. Clinical chemistry and laboratory medicine : CCLM / FESCC, 38(8), 721-30. https://doi.org/10.1515/CCLM.2000.102

@article{34fdede1c39941cb9e2f80fd6d34bfa2,

title = "Apolipoprotein E polymorphism and serum concentration in Alzheimer's disease in nine European centres: the ApoEurope study. ApoEurope group",

abstract = "As part of the ApoEurope Project, apolipoprotein E (apo E) common polymorphism and serum concentration were determined in 489 Alzheimer's disease patients and 429 controls. Patients and controls were recruited through nine centres in eight European countries. Age, sex ratios and education levels of both case and control populations were similar, although discrete differences appeared between centres. The prevalence of the epsilon4 allele was higher in Alzheimer's disease than in controls (increased by 140%), while serum apo E concentration was lower by 11.2% (p",

author = "G Siest and P Bertrand and B Qin and B Herbeth and Serot, {J M} and L Masana and J Ribalta and Passmore, {A P} and A Evans and M Ferrari and M Franceschi and J Shepherd and M Cuchel and U Beisiegel and K Zuchowsky and Rukavina, {A S} and J Sertic and M Stojanov and V Kostic and A Mitrevski and V Petrova and C Sass and A Merched and Salonen, {J T} and L Tiret and S Visvikis",

year = "2000",

doi = "10.1515/CCLM.2000.102",

language = "English",

volume = "38",

pages = "721--30",

journal = "Clinical chemistry and laboratory medicine : CCLM / FESCC",

issn = "1434-6621",

publisher = "De Gruyter",

number = "8",

}

Siest, G, Bertrand, P, Qin, B, Herbeth, B, Serot, JM, Masana, L, Ribalta, J, Passmore, AP, Evans, A, Ferrari, M, Franceschi, M, Shepherd, J, Cuchel, M, Beisiegel, U, Zuchowsky, K, Rukavina, AS, Sertic, J, Stojanov, M, Kostic, V, Mitrevski, A, Petrova, V, Sass, C, Merched, A, Salonen, JT, Tiret, L & Visvikis, S 2000, 'Apolipoprotein E polymorphism and serum concentration in Alzheimer's disease in nine European centres: the ApoEurope study. ApoEurope group', Clinical chemistry and laboratory medicine : CCLM / FESCC, vol. 38, no. 8, pp. 721-30. https://doi.org/10.1515/CCLM.2000.102

TY - JOUR

T1 - Apolipoprotein E polymorphism and serum concentration in Alzheimer's disease in nine European centres

T2 - the ApoEurope study. ApoEurope group

AU - Siest, G

AU - Bertrand, P

AU - Qin, B

AU - Herbeth, B

AU - Serot, J M

AU - Masana, L

AU - Ribalta, J

AU - Passmore, A P

AU - Evans, A

AU - Ferrari, M

AU - Franceschi, M

AU - Shepherd, J

AU - Cuchel, M

AU - Beisiegel, U

AU - Zuchowsky, K

AU - Rukavina, A S

AU - Sertic, J

AU - Stojanov, M

AU - Kostic, V

AU - Mitrevski, A

AU - Petrova, V

AU - Sass, C

AU - Merched, A

AU - Salonen, J T

AU - Tiret, L

AU - Visvikis, S

PY - 2000

Y1 - 2000

N2 - As part of the ApoEurope Project, apolipoprotein E (apo E) common polymorphism and serum concentration were determined in 489 Alzheimer's disease patients and 429 controls. Patients and controls were recruited through nine centres in eight European countries. Age, sex ratios and education levels of both case and control populations were similar, although discrete differences appeared between centres. The prevalence of the epsilon4 allele was higher in Alzheimer's disease than in controls (increased by 140%), while serum apo E concentration was lower by 11.2% (p

AB - As part of the ApoEurope Project, apolipoprotein E (apo E) common polymorphism and serum concentration were determined in 489 Alzheimer's disease patients and 429 controls. Patients and controls were recruited through nine centres in eight European countries. Age, sex ratios and education levels of both case and control populations were similar, although discrete differences appeared between centres. The prevalence of the epsilon4 allele was higher in Alzheimer's disease than in controls (increased by 140%), while serum apo E concentration was lower by 11.2% (p

U2 - 10.1515/CCLM.2000.102

DO - 10.1515/CCLM.2000.102

M3 - Article

C2 - 11071064

SN - 1434-6621

VL - 38

SP - 721

EP - 730

JO - Clinical chemistry and laboratory medicine : CCLM / FESCC

JF - Clinical chemistry and laboratory medicine : CCLM / FESCC

IS - 8

ER -

Apolipoprotein E polymorphism and serum concentration in Alzheimer's disease in nine European centres: the ApoEurope study. ApoEurope group

Abstract

Access to Document

Fingerprint

Cite this