Apolipoprotein E polymorphism and serum concentration in Alzheimer's disease in nine European centres: the ApoEurope study. ApoEurope group

G Siest, P Bertrand, B Qin, B Herbeth, J M Serot, L Masana, J Ribalta, A P Passmore, A Evans, M Ferrari, M Franceschi, J Shepherd, M Cuchel, U Beisiegel, K Zuchowsky, A S Rukavina, J Sertic, M Stojanov, V Kostic, A MitrevskiV Petrova, C Sass, A Merched, J T Salonen, L Tiret, S Visvikis

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67 Citations (Scopus)

Abstract

As part of the ApoEurope Project, apolipoprotein E (apo E) common polymorphism and serum concentration were determined in 489 Alzheimer's disease patients and 429 controls. Patients and controls were recruited through nine centres in eight European countries. Age, sex ratios and education levels of both case and control populations were similar, although discrete differences appeared between centres. The prevalence of the epsilon4 allele was higher in Alzheimer's disease than in controls (increased by 140%), while serum apo E concentration was lower by 11.2% (p
Original languageEnglish
Pages (from-to)721-30
Number of pages10
JournalClinical chemistry and laboratory medicine : CCLM / FESCC
Volume38
Issue number8
DOIs
Publication statusPublished - 2000

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