Apoptosis and cell-cycle regulatory proteins in colorectal carcinoma: relationship to tumour stage and patient survival

M.A. Elkablawy, Perry Maxwell, Kathleen Williamson, N. Anderson, Peter Hamilton

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The quantitative assessment of apoptotic index (AI) and mitotic index (MI) and the immunoreactivity of p53, bcl-2, p21, and mdm2 were examined in tumour and adjacent normal tissue samples from 30 patients with colonic and 22 with rectal adenocarcinoma. Individual features and combined profiles were correlated with clinicopathological parameters and patient survival data to assess their prognostic value. Increased AI was significantly associated with increased bcl-2 expression (p
Original languageEnglish
Pages (from-to)436-443
Number of pages8
JournalJournal of Pathology
Volume194(4)
Issue number4
DOIs
Publication statusPublished - Aug 2001

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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