Apoptosis induction by oxidized glycated LDL in human retinal capillary pericytes is independent of activation of MAPK signaling pathways

J Matthew Diffley, Mingyuan Wu, Mimi Sohn, Weiwei Song, Samar M Hammad, Timothy J Lyons

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Pericyte loss is a cardinal feature of early diabetic retinopathy. We previously reported that highly oxidized-glycated low density lipoprotein (HOG-LDL) induces pericyte apoptosis in vitro. In this study, we investigated the role of the mitogen-activated protein kinase (MAPK) signaling pathways in HOG-LDL-induced apoptosis in human pericytes.
Original languageEnglish
Pages (from-to)135-45
Number of pages11
JournalMolecular Vision
Volume15
Publication statusPublished - 2009

Keywords

  • Anthracenes
  • Apoptosis
  • Butadienes
  • Capillaries
  • Extracellular Signal-Regulated MAP Kinases
  • Humans
  • Imidazoles
  • JNK Mitogen-Activated Protein Kinases
  • Lipoproteins, LDL
  • MAP Kinase Signaling System
  • Nitriles
  • Pericytes
  • Phosphorylation
  • Protein Kinase Inhibitors
  • Pyridines
  • Retinal Vessels
  • Time Factors
  • p38 Mitogen-Activated Protein Kinases

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