Apoptosis induction by oxidized glycated LDL in human retinal capillary pericytes is independent of activation of MAPK signaling pathways

J Matthew Diffley; Mingyuan Wu; Mimi Sohn; Weiwei Song; Samar M Hammad; Timothy J Lyons

Apoptosis induction by oxidized glycated LDL in human retinal capillary pericytes is independent of activation of MAPK signaling pathways

J Matthew Diffley, Mingyuan Wu, Mimi Sohn, Weiwei Song, Samar M Hammad, Timothy J Lyons

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Pericyte loss is a cardinal feature of early diabetic retinopathy. We previously reported that highly oxidized-glycated low density lipoprotein (HOG-LDL) induces pericyte apoptosis in vitro. In this study, we investigated the role of the mitogen-activated protein kinase (MAPK) signaling pathways in HOG-LDL-induced apoptosis in human pericytes.

Original language	English
Pages (from-to)	135-45
Number of pages	11
Journal	Molecular Vision
Volume	15
Publication status	Published - 2009

Keywords

Anthracenes
Apoptosis
Butadienes
Capillaries
Extracellular Signal-Regulated MAP Kinases
Humans
Imidazoles
JNK Mitogen-Activated Protein Kinases
Lipoproteins, LDL
MAP Kinase Signaling System
Nitriles
Pericytes
Phosphorylation
Protein Kinase Inhibitors
Pyridines
Retinal Vessels
Time Factors
p38 Mitogen-Activated Protein Kinases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{b91dba971d0f40f5a9316c36458fa5da,

title = "Apoptosis induction by oxidized glycated LDL in human retinal capillary pericytes is independent of activation of MAPK signaling pathways",

abstract = "Pericyte loss is a cardinal feature of early diabetic retinopathy. We previously reported that highly oxidized-glycated low density lipoprotein (HOG-LDL) induces pericyte apoptosis in vitro. In this study, we investigated the role of the mitogen-activated protein kinase (MAPK) signaling pathways in HOG-LDL-induced apoptosis in human pericytes.",

keywords = "Anthracenes, Apoptosis, Butadienes, Capillaries, Extracellular Signal-Regulated MAP Kinases, Humans, Imidazoles, JNK Mitogen-Activated Protein Kinases, Lipoproteins, LDL, MAP Kinase Signaling System, Nitriles, Pericytes, Phosphorylation, Protein Kinase Inhibitors, Pyridines, Retinal Vessels, Time Factors, p38 Mitogen-Activated Protein Kinases",

author = "Diffley, {J Matthew} and Mingyuan Wu and Mimi Sohn and Weiwei Song and Hammad, {Samar M} and Lyons, {Timothy J}",

year = "2009",

language = "English",

volume = "15",

pages = "135--45",

journal = "Molecular Vision",

issn = "1090-0535",

publisher = "Molecular Vision",

}

TY - JOUR

T1 - Apoptosis induction by oxidized glycated LDL in human retinal capillary pericytes is independent of activation of MAPK signaling pathways

AU - Diffley, J Matthew

AU - Wu, Mingyuan

AU - Sohn, Mimi

AU - Song, Weiwei

AU - Hammad, Samar M

AU - Lyons, Timothy J

PY - 2009

Y1 - 2009

N2 - Pericyte loss is a cardinal feature of early diabetic retinopathy. We previously reported that highly oxidized-glycated low density lipoprotein (HOG-LDL) induces pericyte apoptosis in vitro. In this study, we investigated the role of the mitogen-activated protein kinase (MAPK) signaling pathways in HOG-LDL-induced apoptosis in human pericytes.

AB - Pericyte loss is a cardinal feature of early diabetic retinopathy. We previously reported that highly oxidized-glycated low density lipoprotein (HOG-LDL) induces pericyte apoptosis in vitro. In this study, we investigated the role of the mitogen-activated protein kinase (MAPK) signaling pathways in HOG-LDL-induced apoptosis in human pericytes.

KW - Anthracenes

KW - Apoptosis

KW - Butadienes

KW - Capillaries

KW - Extracellular Signal-Regulated MAP Kinases

KW - Humans

KW - Imidazoles

KW - JNK Mitogen-Activated Protein Kinases

KW - Lipoproteins, LDL

KW - MAP Kinase Signaling System

KW - Nitriles

KW - Pericytes

KW - Phosphorylation

KW - Protein Kinase Inhibitors

KW - Pyridines

KW - Retinal Vessels

KW - Time Factors

KW - p38 Mitogen-Activated Protein Kinases

M3 - Article

C2 - 19158958

SN - 1090-0535

VL - 15

SP - 135

EP - 145

JO - Molecular Vision

JF - Molecular Vision

ER -

Apoptosis induction by oxidized glycated LDL in human retinal capillary pericytes is independent of activation of MAPK signaling pathways

Abstract

Keywords

UN SDGs

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