Apoptosomes: protease activation platforms to die from

Colin Adrain, Gabriela Brumatti, Seamus J Martin

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)


Apoptosis is orchestrated by members of the caspase family of cysteine proteases that exist as latent pro-enzymes in healthy cells. Caspase-activating platforms, called apoptosomes, initiate caspase activation in metazoans as diverse as nematodes and mammals. Several recent studies have generated new insights into the composition and assembly mechanisms of worm, fly and human apoptosomes.

Original languageEnglish
Pages (from-to)243-7
Number of pages5
JournalTrends in Biochemical Sciences
Issue number5
Publication statusPublished - May 2006
Externally publishedYes


  • Animals
  • Apoptosis
  • Caspases/classification
  • Enzyme Activation
  • Humans
  • Models, Biological
  • Models, Molecular


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