Application of ω-Transaminases in the Pharmaceutical Industry

Stephen A. Kelly; Stefan Pohle; Scott Wharry; Stefan Mix; Christopher C.R. Allen; Thomas S. Moody; Brendan F. Gilmore

doi:10.1021/acs.chemrev.7b00437

Application of ω-Transaminases in the Pharmaceutical Industry

Stephen A. Kelly, Stefan Pohle, Scott Wharry, Stefan Mix, Christopher C.R. Allen, Thomas S. Moody, Brendan F. Gilmore^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

272 Citations (Scopus)

Abstract

Chiral amines are valuable building blocks for the pharmaceutical industry. ω-TAms have emerged as an exciting option for their synthesis, offering a potential "green alternative" to overcome the drawbacks associated with conventional chemical methods. In this review, we explore the application of ω-TAms for pharmaceutical production. We discuss the diverse array of reactions available involving ω-TAms and process considerations of their use in both kinetic resolution and asymmetric synthesis. With the aid of specific drug intermediates and APIs, we chart the development of ω-TAms using protein engineering and their contribution to elegant one-pot cascades with other enzymes, including carbonyl reductases (CREDs), hydrolases and monoamine oxidases (MAOs), providing a comprehensive overview of their uses, beginning with initial applications through to the present day.

Original language	English
Pages (from-to)	349-367
Number of pages	19
Journal	Chemical Reviews
Volume	118
Issue number	1
DOIs	https://doi.org/10.1021/acs.chemrev.7b00437 https://doi.org/10.1021/acs.chemrev.7b00437
Publication status	Published - 10 Jan 2018

Keywords

Alcohol Oxidoreductases/chemistry
Amines/metabolism
Biocatalysis
Drug Industry
Monoamine Oxidase/chemistry
Protein Engineering
Stereoisomerism
Transaminases/chemistry

ASJC Scopus subject areas

General Chemistry

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Cite this

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title = "Application of ω-Transaminases in the Pharmaceutical Industry",

abstract = "Chiral amines are valuable building blocks for the pharmaceutical industry. ω-TAms have emerged as an exciting option for their synthesis, offering a potential {"}green alternative{"} to overcome the drawbacks associated with conventional chemical methods. In this review, we explore the application of ω-TAms for pharmaceutical production. We discuss the diverse array of reactions available involving ω-TAms and process considerations of their use in both kinetic resolution and asymmetric synthesis. With the aid of specific drug intermediates and APIs, we chart the development of ω-TAms using protein engineering and their contribution to elegant one-pot cascades with other enzymes, including carbonyl reductases (CREDs), hydrolases and monoamine oxidases (MAOs), providing a comprehensive overview of their uses, beginning with initial applications through to the present day.",

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AU - Kelly, Stephen A.

AU - Pohle, Stefan

AU - Wharry, Scott

AU - Mix, Stefan

AU - Allen, Christopher C.R.

AU - Moody, Thomas S.

AU - Gilmore, Brendan F.

PY - 2018/1/10

Y1 - 2018/1/10

N2 - Chiral amines are valuable building blocks for the pharmaceutical industry. ω-TAms have emerged as an exciting option for their synthesis, offering a potential "green alternative" to overcome the drawbacks associated with conventional chemical methods. In this review, we explore the application of ω-TAms for pharmaceutical production. We discuss the diverse array of reactions available involving ω-TAms and process considerations of their use in both kinetic resolution and asymmetric synthesis. With the aid of specific drug intermediates and APIs, we chart the development of ω-TAms using protein engineering and their contribution to elegant one-pot cascades with other enzymes, including carbonyl reductases (CREDs), hydrolases and monoamine oxidases (MAOs), providing a comprehensive overview of their uses, beginning with initial applications through to the present day.

AB - Chiral amines are valuable building blocks for the pharmaceutical industry. ω-TAms have emerged as an exciting option for their synthesis, offering a potential "green alternative" to overcome the drawbacks associated with conventional chemical methods. In this review, we explore the application of ω-TAms for pharmaceutical production. We discuss the diverse array of reactions available involving ω-TAms and process considerations of their use in both kinetic resolution and asymmetric synthesis. With the aid of specific drug intermediates and APIs, we chart the development of ω-TAms using protein engineering and their contribution to elegant one-pot cascades with other enzymes, including carbonyl reductases (CREDs), hydrolases and monoamine oxidases (MAOs), providing a comprehensive overview of their uses, beginning with initial applications through to the present day.

KW - Alcohol Oxidoreductases/chemistry

KW - Amines/metabolism

KW - Biocatalysis

KW - Drug Industry

KW - Monoamine Oxidase/chemistry

KW - Protein Engineering

KW - Stereoisomerism

KW - Transaminases/chemistry

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Application of ω-Transaminases in the Pharmaceutical Industry

Abstract

Keywords

ASJC Scopus subject areas

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