Application of ω-Transaminases in the Pharmaceutical Industry

Stephen A. Kelly; Stefan Pohle; Scott Wharry; Stefan Mix; Christopher C.R. Allen; Thomas S. Moody; Brendan F. Gilmore

doi:10.1021/acs.chemrev.7b00437

Application of ω-Transaminases in the Pharmaceutical Industry

Stephen A. Kelly, Stefan Pohle, Scott Wharry, Stefan Mix, Christopher C.R. Allen, Thomas S. Moody, Brendan F. Gilmore^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article

82 Citations (Scopus)

Abstract

Chiral amines are valuable building blocks for the pharmaceutical industry. ω-TAms have emerged as an exciting option for their synthesis, offering a potential "green alternative" to overcome the drawbacks associated with conventional chemical methods. In this review, we explore the application of ω-TAms for pharmaceutical production. We discuss the diverse array of reactions available involving ω-TAms and process considerations of their use in both kinetic resolution and asymmetric synthesis. With the aid of specific drug intermediates and APIs, we chart the development of ω-TAms using protein engineering and their contribution to elegant one-pot cascades with other enzymes, including carbonyl reductases (CREDs), hydrolases and monoamine oxidases (MAOs), providing a comprehensive overview of their uses, beginning with initial applications through to the present day.

Original language	English
Pages (from-to)	349-367
Number of pages	19
Journal	Chemical Reviews
Volume	118
Issue number	1
DOIs	https://doi.org/10.1021/acs.chemrev.7b00437 https://doi.org/10.1021/acs.chemrev.7b00437
Publication status	Published - 10 Jan 2018

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Keywords

Alcohol Oxidoreductases/chemistry
Amines/metabolism
Biocatalysis
Drug Industry
Monoamine Oxidase/chemistry
Protein Engineering
Stereoisomerism
Transaminases/chemistry

Cite this

Kelly, S. A., Pohle, S., Wharry, S., Mix, S., Allen, C. C. R., Moody, T. S., & Gilmore, B. F. (2018). Application of ω-Transaminases in the Pharmaceutical Industry. Chemical Reviews, 118(1), 349-367. https://doi.org/10.1021/acs.chemrev.7b00437, https://doi.org/10.1021/acs.chemrev.7b00437

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AU - Moody, Thomas S.

AU - Gilmore, Brendan F.

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10.1021/acs.chemrev.7b00437Licence: Unspecified
10.1021/acs.chemrev.7b00437

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