Application of ω-Transaminases in the Pharmaceutical Industry

Stephen A. Kelly, Stefan Pohle, Scott Wharry, Stefan Mix, Christopher C.R. Allen, Thomas S. Moody, Brendan F. Gilmore

Research output: Contribution to journalReview article

55 Citations (Scopus)

Abstract

Chiral amines are valuable building blocks for the pharmaceutical industry. ω-TAms have emerged as an exciting option for their synthesis, offering a potential "green alternative" to overcome the drawbacks associated with conventional chemical methods. In this review, we explore the application of ω-TAms for pharmaceutical production. We discuss the diverse array of reactions available involving ω-TAms and process considerations of their use in both kinetic resolution and asymmetric synthesis. With the aid of specific drug intermediates and APIs, we chart the development of ω-TAms using protein engineering and their contribution to elegant one-pot cascades with other enzymes, including carbonyl reductases (CREDs), hydrolases and monoamine oxidases (MAOs), providing a comprehensive overview of their uses, beginning with initial applications through to the present day.

LanguageEnglish
Pages349-367
Number of pages19
JournalChemical Reviews
Volume118
Issue number1
DOIs
Publication statusPublished - 10 Jan 2018

Fingerprint

Transaminases
Alcohol Oxidoreductases
Pharmaceutical Preparations
Industry
Monoamine Oxidase
Hydrolases
Application programming interfaces (API)
Amines
Kinetics
Enzymes
Proteins

Keywords

  • Alcohol Oxidoreductases/chemistry
  • Amines/metabolism
  • Biocatalysis
  • Drug Industry
  • Monoamine Oxidase/chemistry
  • Protein Engineering
  • Stereoisomerism
  • Transaminases/chemistry

Cite this

Kelly, Stephen A. ; Pohle, Stefan ; Wharry, Scott ; Mix, Stefan ; Allen, Christopher C.R. ; Moody, Thomas S. ; Gilmore, Brendan F. / Application of ω-Transaminases in the Pharmaceutical Industry. In: Chemical Reviews. 2018 ; Vol. 118, No. 1. pp. 349-367.
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Application of ω-Transaminases in the Pharmaceutical Industry. / Kelly, Stephen A.; Pohle, Stefan; Wharry, Scott; Mix, Stefan; Allen, Christopher C.R.; Moody, Thomas S.; Gilmore, Brendan F.

In: Chemical Reviews, Vol. 118, No. 1, 10.01.2018, p. 349-367.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Application of ω-Transaminases in the Pharmaceutical Industry

AU - Kelly, Stephen A.

AU - Pohle, Stefan

AU - Wharry, Scott

AU - Mix, Stefan

AU - Allen, Christopher C.R.

AU - Moody, Thomas S.

AU - Gilmore, Brendan F.

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KW - Amines/metabolism

KW - Biocatalysis

KW - Drug Industry

KW - Monoamine Oxidase/chemistry

KW - Protein Engineering

KW - Stereoisomerism

KW - Transaminases/chemistry

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