Application of ω-Transaminases in the Pharmaceutical Industry

Stephen A. Kelly, Stefan Pohle, Scott Wharry, Stefan Mix, Christopher C.R. Allen, Thomas S. Moody, Brendan F. Gilmore*

*Corresponding author for this work

Research output: Contribution to journalReview article

82 Citations (Scopus)

Abstract

Chiral amines are valuable building blocks for the pharmaceutical industry. ω-TAms have emerged as an exciting option for their synthesis, offering a potential "green alternative" to overcome the drawbacks associated with conventional chemical methods. In this review, we explore the application of ω-TAms for pharmaceutical production. We discuss the diverse array of reactions available involving ω-TAms and process considerations of their use in both kinetic resolution and asymmetric synthesis. With the aid of specific drug intermediates and APIs, we chart the development of ω-TAms using protein engineering and their contribution to elegant one-pot cascades with other enzymes, including carbonyl reductases (CREDs), hydrolases and monoamine oxidases (MAOs), providing a comprehensive overview of their uses, beginning with initial applications through to the present day.

Original languageEnglish
Pages (from-to)349-367
Number of pages19
JournalChemical Reviews
Volume118
Issue number1
DOIs
Publication statusPublished - 10 Jan 2018

    Fingerprint

Keywords

  • Alcohol Oxidoreductases/chemistry
  • Amines/metabolism
  • Biocatalysis
  • Drug Industry
  • Monoamine Oxidase/chemistry
  • Protein Engineering
  • Stereoisomerism
  • Transaminases/chemistry

Cite this