Application of connectivity mapping in predictive toxicology based on gene-expression similarity.

J.L. Smalley, T.W. Gant, Shu-Dong Zhang

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)


Connectivity mapping is the process of establishing connections between different biological states using gene-expression profiles or signatures. There are a number of applications but in toxicology the most pertinent is for understanding mechanisms of toxicity. In its essence the process involves comparing a query gene signature generated as a result of exposure of a biological system to a chemical to those in a database that have been previously derived. In the ideal situation the query gene-expression signature is characteristic of the event and will be matched to similar events in the database. Key criteria are therefore the means of choosing the signature to be matched and the means by which the match is made. In this article we explore these concepts with examples applicable to toxicology.
Original languageEnglish
Pages (from-to)143-146
Number of pages4
Issue number3
Publication statusPublished - 09 Feb 2010

ASJC Scopus subject areas

  • Toxicology


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