Applications of microarrays and biochips in pharmacogenomics

Gary Hardiman*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Citations (Scopus)

Abstract

The complete sequence of the human genome and subsequent intensive searches for polymorphic variations are providing the prerequisite markers necessary to facilitate elucidation of the genetic variability in drug responses. Improvements in the sensitivity and precision of DNA microarrays permit a detailed and accurate scrutiny of the human genome. These advances have the potential to significantly improve health care management by improving disease diagnosis and targeting molecular therapy. Pharmacogenetic approaches, in limited use today, will become an integral part of therapeutic monitoring and health management, permitting patient stratification in advance of treatments, with the potential to eliminate adverse drug reactions. In this chapter, the current state of biochip technology is discussed, and recent applications in the arena of clinic diagnostics are explored.

Original languageEnglish
Title of host publicationPharmacogenomics in Drug Discovery and Development
Subtitle of host publicationFrom Bench to Bedside
PublisherHumana Press
Pages21-30
Number of pages10
ISBN (Print)9781588298874
DOIs
Publication statusPublished - 01 Jan 2008
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume448
ISSN (Print)1064-3745

Keywords

  • AmpliChip
  • Biochips
  • Microarrays
  • P450
  • Pharmacogenetics

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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  • Cite this

    Hardiman, G. (2008). Applications of microarrays and biochips in pharmacogenomics. In Pharmacogenomics in Drug Discovery and Development: From Bench to Bedside (pp. 21-30). (Methods in Molecular Biology; Vol. 448). Humana Press. https://doi.org/10.1007/978-1-59745-205-2_2