TY - JOUR
T1 - Arene cis-Diol Dehydrogenase-Catalysed Regio- and Stereoselective Oxidation of Arene-, Cycloalkane- and Cycloalkene-cis-diols to Yield Catechols and Chiral α-Ketols
AU - Boyd, Derek R.
AU - Sharma, Narain D.
AU - Berberian, M. Victoria
AU - Cleij, Marcel
AU - Hardacre, Christopher
AU - Ljubez, Vera
AU - McConville, Gareth
AU - Stevenson, Paul J.
AU - Kulakov, Leonid A.
AU - Allen, Christopher C. R.
PY - 2015/5/26
Y1 - 2015/5/26
N2 - Benzene cis-diol dehydrogenase and naphthalene cis-diol dehydrogenase enzymes, expressed in Pseudomonas putida wild-type and Escherichia coli recombinant strains, were used to investigate regioselectivity and stereoselectivity during dehydrogenations of arene, cyclic alkane and cyclic alkene vicinal cis-diols. The dehydrogenase-catalysed production of enantiopure cis-diols, α-ketols and catechols, using benzene cis-diol dehydrogenase and naphthalene cis-diol dehydrogenase, involved both kinetic resolution and asymmetric synthesis methods. The chemoenzymatic production and applications of catechol bioproducts in synthesis were investigated.
AB - Benzene cis-diol dehydrogenase and naphthalene cis-diol dehydrogenase enzymes, expressed in Pseudomonas putida wild-type and Escherichia coli recombinant strains, were used to investigate regioselectivity and stereoselectivity during dehydrogenations of arene, cyclic alkane and cyclic alkene vicinal cis-diols. The dehydrogenase-catalysed production of enantiopure cis-diols, α-ketols and catechols, using benzene cis-diol dehydrogenase and naphthalene cis-diol dehydrogenase, involved both kinetic resolution and asymmetric synthesis methods. The chemoenzymatic production and applications of catechol bioproducts in synthesis were investigated.
UR - http://www.scopus.com/inward/record.url?scp=84930200829&partnerID=8YFLogxK
U2 - 10.1002/adsc.201500189
DO - 10.1002/adsc.201500189
M3 - Article
SN - 1615-4150
VL - 357
SP - 1881
EP - 1894
JO - Advanced Synthesis and Catalysis
JF - Advanced Synthesis and Catalysis
IS - 8
ER -
