Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms.

I. Stalmans, Y.S. Ng, R. Rohan, M. Fruttiger, A. Bouche, A. Yuce, H. Fujisawa, B. Hermans, M. Shani, S. Jansen, D. Hicklin, D.J. Anderson, Tom Gardiner, H.P. Hammes, L. Moons, M. Dewerchin, D. Collen, P. Carmeliet, P.A. D'Amore

Research output: Contribution to journalArticle

408 Citations (Scopus)

Abstract

The murine VEGF gene is alternatively transcribed to yield the VEGF120, VEGF164, and VEGF188 isoforms, which differ in their potential to bind to heparan sulfate and neuropilin-1 and to stimulate endothelial growth. Here, their role in retinal vascular development was studied in mice selectively expressing single isoforms. VEGF164/164 mice were normal, healthy, and had normal retinal angiogenesis. In contrast, VEGF120/120 mice exhibited severe defects in vascular outgrowth and patterning, whereas VEGF188/188 mice displayed normal venular outgrowth but impaired arterial development. It is noteworthy that neuropilin-1, a receptor for VEGF164, was predominantly expressed in retinal arterioles. These findings reveal distinct roles of the various VEGF isoforms in vascular patterning and arterial development in the retina.
Original languageEnglish
Pages (from-to)327-336
Number of pages10
JournalJournal of Clinical Investigation
Volume109(3)
Issue number3
DOIs
Publication statusPublished - Feb 2002

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms.'. Together they form a unique fingerprint.

  • Cite this

    Stalmans, I., Ng, Y. S., Rohan, R., Fruttiger, M., Bouche, A., Yuce, A., Fujisawa, H., Hermans, B., Shani, M., Jansen, S., Hicklin, D., Anderson, D. J., Gardiner, T., Hammes, H. P., Moons, L., Dewerchin, M., Collen, D., Carmeliet, P., & D'Amore, P. A. (2002). Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms. Journal of Clinical Investigation, 109(3)(3), 327-336. https://doi.org/10.1172/JCI200214362