Assessment of cell-mediated immunity in a British population using multiple skin test antigens

A P Maxwell, D R McCluskey

Research output: Contribution to journalArticle

Abstract

An in vivo method of assessing the competence of the cell-mediated immune system (Multitest CMI) was used in 200 healthy volunteers (age range 17-88 years). The profile of reactivity to seven individual antigens was determined. A positive reaction was obtained in 96.5% of the subjects who reacted positively to at least one antigen with 78% reacting to two or more antigens. The number of positive responses and the degree of reactivity was significantly reduced in elderly subjects and in females aged 17-65 years. The Multitest CMI system provides a rapid and convenient method of assessing cell-mediated immunity (CMI) in vivo and could have a wide range of applications in the investigation of immunological, infective and neoplastic conditions.
Original languageEnglish
Pages (from-to)365-9
Number of pages5
JournalClinical & Experimental Allergy
Volume16
Issue number4
Publication statusPublished - 1986

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