Assessment of cold atmospheric pressure plasma (CAPP) treatment for degradation of antibiotic residues in water

Ewa Wielogorska; Padrig B. Flynn; Julie Meneely; Thomas P. Thompson; William G. Graham; Brendan F. Gilmore; Christopher T. Elliott

doi:10.3390/antibiotics12071115

Assessment of cold atmospheric pressure plasma (CAPP) treatment for degradation of antibiotic residues in water

Ewa Wielogorska^*
, Padrig B. Flynn
, Julie Meneely
, Thomas P. Thompson
, William G. Graham
, Brendan F. Gilmore^*
, Christopher T. Elliott^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

94 Downloads (Pure)

Abstract

The presence of antibiotic residues in water is linked to the emergence of antibiotic resistance globally and necessitates novel decontamination strategies to minimize antibiotic residue exposure in both the environment and food. A holistic assessment of cold atmospheric pressure plasma technology (CAPP) for β-lactam antibiotic residue removal is described in this study. CAPP operating parameters including plasma jet voltage, gas composition and treatment time were optimized, with highest β-lactam degradation efficiencies obtained for a helium jet operated at 6 kV. Main by-products detected indicate pH-driven peroxidation as a main mechanism of CAPP-induced decomposition of β-lactams. No in vitro hepatocytotoxicity was observed in HepG2 cells following exposure to treated samples, and E. coli exposed to CAPP-degraded β-lactams did not exhibit resistance development. In surface water, over 50% decrease in antibiotic levels was achieved after only 5 min of treatment. However, high dependence of treatment efficiency on residue concentration, pH and presence of polar macromolecules was observed.

Original language	English
Article number	1115
Number of pages	16
Journal	Antibiotics
Volume	12
Issue number	7
Early online date	28 Jun 2023
DOIs	https://doi.org/10.3390/antibiotics12071115
Publication status	Published - Jul 2023

Bibliographical note

Funding Information:
This research was funded by (UKRI) BBSRC-SFI (Science Foundation Ireland), grant number BB/P008486/1 ‘EnvironSafe: Cold Plasma Applications for Food Safety and Sustainability’.

Publisher Copyright:
© 2023 by the authors.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cold atmospheric pressure plasma
antibiotics
antibiotic resistance
surface water

ASJC Scopus subject areas

Microbiology
Biochemistry
Pharmacology, Toxicology and Pharmaceutics(all)
Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

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10.3390/antibiotics12071115Licence: CC BY

Assessment of Cold Atmospheric Pressure Plasma (CAPP) Treatment for Degradation of Antibiotic Residues in Water
© 2023 The Authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 3.05 MBLicence: CC BY

Cite this

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title = "Assessment of cold atmospheric pressure plasma (CAPP) treatment for degradation of antibiotic residues in water",

abstract = "The presence of antibiotic residues in water is linked to the emergence of antibiotic resistance globally and necessitates novel decontamination strategies to minimize antibiotic residue exposure in both the environment and food. A holistic assessment of cold atmospheric pressure plasma technology (CAPP) for β-lactam antibiotic residue removal is described in this study. CAPP operating parameters including plasma jet voltage, gas composition and treatment time were optimized, with highest β-lactam degradation efficiencies obtained for a helium jet operated at 6 kV. Main by-products detected indicate pH-driven peroxidation as a main mechanism of CAPP-induced decomposition of β-lactams. No in vitro hepatocytotoxicity was observed in HepG2 cells following exposure to treated samples, and E. coli exposed to CAPP-degraded β-lactams did not exhibit resistance development. In surface water, over 50\% decrease in antibiotic levels was achieved after only 5 min of treatment. However, high dependence of treatment efficiency on residue concentration, pH and presence of polar macromolecules was observed.",

keywords = "cold atmospheric pressure plasma, antibiotics, antibiotic resistance, surface water",

author = "Ewa Wielogorska and Flynn, \{Padrig B.\} and Julie Meneely and Thompson, \{Thomas P.\} and Graham, \{William G.\} and Gilmore, \{Brendan F.\} and Elliott, \{Christopher T.\}",

note = "Funding Information: This research was funded by (UKRI) BBSRC-SFI (Science Foundation Ireland), grant number BB/P008486/1 {\textquoteleft}EnvironSafe: Cold Plasma Applications for Food Safety and Sustainability{\textquoteright}. Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

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doi = "10.3390/antibiotics12071115",

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journal = "Antibiotics",

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AU - Wielogorska, Ewa

AU - Flynn, Padrig B.

AU - Meneely, Julie

AU - Thompson, Thomas P.

AU - Graham, William G.

AU - Gilmore, Brendan F.

AU - Elliott, Christopher T.

N1 - Funding Information: This research was funded by (UKRI) BBSRC-SFI (Science Foundation Ireland), grant number BB/P008486/1 ‘EnvironSafe: Cold Plasma Applications for Food Safety and Sustainability’. Publisher Copyright: © 2023 by the authors.

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N2 - The presence of antibiotic residues in water is linked to the emergence of antibiotic resistance globally and necessitates novel decontamination strategies to minimize antibiotic residue exposure in both the environment and food. A holistic assessment of cold atmospheric pressure plasma technology (CAPP) for β-lactam antibiotic residue removal is described in this study. CAPP operating parameters including plasma jet voltage, gas composition and treatment time were optimized, with highest β-lactam degradation efficiencies obtained for a helium jet operated at 6 kV. Main by-products detected indicate pH-driven peroxidation as a main mechanism of CAPP-induced decomposition of β-lactams. No in vitro hepatocytotoxicity was observed in HepG2 cells following exposure to treated samples, and E. coli exposed to CAPP-degraded β-lactams did not exhibit resistance development. In surface water, over 50% decrease in antibiotic levels was achieved after only 5 min of treatment. However, high dependence of treatment efficiency on residue concentration, pH and presence of polar macromolecules was observed.

AB - The presence of antibiotic residues in water is linked to the emergence of antibiotic resistance globally and necessitates novel decontamination strategies to minimize antibiotic residue exposure in both the environment and food. A holistic assessment of cold atmospheric pressure plasma technology (CAPP) for β-lactam antibiotic residue removal is described in this study. CAPP operating parameters including plasma jet voltage, gas composition and treatment time were optimized, with highest β-lactam degradation efficiencies obtained for a helium jet operated at 6 kV. Main by-products detected indicate pH-driven peroxidation as a main mechanism of CAPP-induced decomposition of β-lactams. No in vitro hepatocytotoxicity was observed in HepG2 cells following exposure to treated samples, and E. coli exposed to CAPP-degraded β-lactams did not exhibit resistance development. In surface water, over 50% decrease in antibiotic levels was achieved after only 5 min of treatment. However, high dependence of treatment efficiency on residue concentration, pH and presence of polar macromolecules was observed.

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KW - antibiotic resistance

KW - surface water

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DO - 10.3390/antibiotics12071115

M3 - Article

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VL - 12

JO - Antibiotics

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M1 - 1115

ER -

Assessment of cold atmospheric pressure plasma (CAPP) treatment for degradation of antibiotic residues in water

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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Cite this