Assessment of dietary exposure to ochratoxin A in the UK using a duplicate diet approach and analysis of urine and plasma samples

J. Gilbert*, P. Brereton, S. MacDonald

*Corresponding author for this work

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

The approach to assess exposure to ochratoxin A from the diet by the analysis of human plasma and urine samples has been developed. Composite duplicate diet samples from 50 individuals and corresponding plasma and urine samples were obtained over 30 days. Samples were analysed using sensitive methods capable of measuring ochratoxin A at 0.001 ng g-1 in food, 0.1 ng ml-1 in plasma and 0.01 ng ml-1 in urine. Analysis of the foods indicated ochratoxin A levels contributing to an average intake in the range 0.26-3.54 ng kg-1 bw day-1 over the 30 days. Ochratoxin A was found in all plasma samples and in 46 urine samples. The correlation between the plasma ochratoxin A levels and ochratoxin A consumption was not significant (95%) confidence limit). However, a significant correlation was found between ochratoxin A consumption and the urine ochratoxin A concentration expressed as the total amount excreted. This new work offers the possibility of using ochratoxin A in urine as a simple and reliable biomarker to estimate exposure to this mycotoxin.

Original languageEnglish
Pages (from-to)1088-1093
Number of pages6
JournalFood Additives and Contaminants
Volume18
Issue number12
DOIs
Publication statusPublished - 13 Dec 2001
Externally publishedYes

Keywords

  • Biomakers
  • Duplicate diets
  • Intake
  • Ochratoxin A
  • Plasma
  • Urine

ASJC Scopus subject areas

  • Food Science
  • Chemistry (miscellaneous)
  • Toxicology
  • Health, Toxicology and Mutagenesis

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