Assessment of Ki-67 and mitoses in pituitary neuroendocrine tumours: consistency counts

Paul Benjamin Loughrey; Christine Greene; Kris D. McCombe; Fatima Abdullahi Sidi; Stephen McQuaid; Stephen Cooke; Steven J. Hunter; Brian Herron; Márta Korbonits; Stephanie G. Craig; Jacqueline A. James

doi:10.1111/bpa.13285

Assessment of Ki-67 and mitoses in pituitary neuroendocrine tumours: consistency counts

Paul Benjamin Loughrey^*
, Christine Greene
, Kris D. McCombe
, Fatima Abdullahi Sidi
, Stephen McQuaid
, Stephen Cooke
, Steven J. Hunter
, Brian Herron
, Márta Korbonits
, Stephanie G. Craig
, Jacqueline A. James^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

134 Downloads (Pure)

Abstract

Pituitary neuroendocrine tumour Ki-67 proliferation index varies according to the number of tumour cells assessed. Consistent Ki-67 scoring approaches and re-evaluation of the recommended Ki-67 3% cut-off are required to clarify controversies in pituitary neuroendocrine tumour Ki-67 proliferation index assessment.

Original language	English
Article number	e13285
Number of pages	5
Journal	Brain Pathology
Early online date	15 Jul 2024
DOIs	https://doi.org/10.1111/bpa.13285
Publication status	Early online date - 15 Jul 2024

Keywords

Pituitary
Pituitary Neuroendocrine Tumour
Pituitary adenoma
Acromegaly
Cushing's
Neuroendocrinology
Digital pathology
Ki-67
Mitoses

Access to Document

10.1111/bpa.13285Licence: CC BY

Assessment of Ki-67 and mitoses in pituitary neuroendocrine tumours — consistency counts
© 2024 The Authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 1.09 MBLicence: CC BY

Clinical, genetic and molecular correlations in pituitary neuroendocrine tumours
Loughrey, P. B. (Author), James, J. (Supervisor), Craig, S. (Supervisor), Korbonits, M. (Supervisor) & Hunter, S. (Supervisor), Dec 2023
Student thesis: Doctoral Thesis › Doctor of Philosophy
The prognostic value of tertiary lymphoid structures in cancer; a digital pathology and artificial intelligence approach
McCombe, K. D. (Author), Craig, S. (Supervisor), Gault, R. (Supervisor) & James, J. (Supervisor), Dec 2024
Student thesis: Doctoral Thesis › Doctor of Philosophy

4 Citations
1 Conference contribution

To score or not to score? Is Ki-67 analysis worthwhile in pituitary neuroendocrine tumours? (Audio ePoster presentation)
Benjamin, L. P., Craig, S., Herron, B., Abdullahi, S. F., McQuaid, S., Kelly, P., Humphries, M., Parkes, E., McArt, D., Hunter, S., Korbonits, M. & James, J., 09 Sept 2020, Endocrine Abstracts 2020. AEP671. (Endocrine Abstracts ).
Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Cite this

@article{ff875a8e4d3049c280551d2f4dc094e8,

title = "Assessment of Ki-67 and mitoses in pituitary neuroendocrine tumours: consistency counts",

abstract = "Pituitary neuroendocrine tumour Ki-67 proliferation index varies according to the number of tumour cells assessed. Consistent Ki-67 scoring approaches and re-evaluation of the recommended Ki-67 3\% cut-off are required to clarify controversies in pituitary neuroendocrine tumour Ki-67 proliferation index assessment. ",

keywords = "Pituitary, Pituitary Neuroendocrine Tumour, Pituitary adenoma, Acromegaly, Cushing's, Neuroendocrinology, Digital pathology, Ki-67, Mitoses",

author = "Loughrey, \{Paul Benjamin\} and Christine Greene and McCombe, \{Kris D.\} and \{Abdullahi Sidi\}, Fatima and Stephen McQuaid and Stephen Cooke and Hunter, \{Steven J.\} and Brian Herron and M{\'a}rta Korbonits and Craig, \{Stephanie G.\} and James, \{Jacqueline A.\}",

year = "2024",

month = jul,

day = "15",

doi = "10.1111/bpa.13285",

language = "English",

journal = "Brain Pathology",

issn = "1750-3639",

publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Assessment of Ki-67 and mitoses in pituitary neuroendocrine tumours: consistency counts

AU - Loughrey, Paul Benjamin

AU - Greene, Christine

AU - McCombe, Kris D.

AU - Abdullahi Sidi, Fatima

AU - McQuaid, Stephen

AU - Cooke, Stephen

AU - Hunter, Steven J.

AU - Herron, Brian

AU - Korbonits, Márta

AU - Craig, Stephanie G.

AU - James, Jacqueline A.

PY - 2024/7/15

Y1 - 2024/7/15

N2 - Pituitary neuroendocrine tumour Ki-67 proliferation index varies according to the number of tumour cells assessed. Consistent Ki-67 scoring approaches and re-evaluation of the recommended Ki-67 3% cut-off are required to clarify controversies in pituitary neuroendocrine tumour Ki-67 proliferation index assessment.

AB - Pituitary neuroendocrine tumour Ki-67 proliferation index varies according to the number of tumour cells assessed. Consistent Ki-67 scoring approaches and re-evaluation of the recommended Ki-67 3% cut-off are required to clarify controversies in pituitary neuroendocrine tumour Ki-67 proliferation index assessment.

KW - Pituitary

KW - Pituitary Neuroendocrine Tumour

KW - Pituitary adenoma

KW - Acromegaly

KW - Cushing's

KW - Neuroendocrinology

KW - Digital pathology

KW - Ki-67

KW - Mitoses

U2 - 10.1111/bpa.13285

DO - 10.1111/bpa.13285

M3 - Article

SN - 1750-3639

JO - Brain Pathology

JF - Brain Pathology

M1 - e13285

ER -

Assessment of Ki-67 and mitoses in pituitary neuroendocrine tumours: consistency counts

Abstract

Keywords

Access to Document

Fingerprint

Student theses

Clinical, genetic and molecular correlations in pituitary neuroendocrine tumours

The prognostic value of tertiary lymphoid structures in cancer; a digital pathology and artificial intelligence approach

Research output

To score or not to score? Is Ki-67 analysis worthwhile in pituitary neuroendocrine tumours? (Audio ePoster presentation)

Cite this