Assessment of three Resistance-Nodulation-Cell Division drug efflux transporters of Burkholderia cenocepacia in intrinsic antibiotic resistance

Silvia Buroni, Maria R Pasca, Ronald S Flannagan, Silvia Bazzini, Anna Milano, Iris Bertani, Vittorio Venturi, Miguel A Valvano, Giovanna Riccardi

Research output: Contribution to journalArticlepeer-review

59 Citations (Scopus)

Abstract

Burkholderia cenocepacia are opportunistic Gram-negative bacteria that can cause chronic pulmonary infections in patients with cystic fibrosis. These bacteria demonstrate a high-level of intrinsic antibiotic resistance to most clinically useful antibiotics complicating treatment. We previously identified 14 genes encoding putative Resistance-Nodulation-Cell Division (RND) efflux pumps in the genome of B. cenocepacia J2315, but the contribution of these pumps to the intrinsic drug resistance of this bacterium remains unclear.
Original languageEnglish
Article number200
Pages (from-to)200
JournalBMC Microbiology
Volume9
DOIs
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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