Association between retinal thickness variation and visual acuity change in neovascular age‐related macular degeneration

Kai Xiong Cheong, Alvin Wei Jun Teo, Chui Ming Gemmy Cheung, Issac Horng Khit Too, Usha Chakravarthy, Kelvin Yi Chong Teo

Research output: Contribution to journalArticlepeer-review

Abstract

Background:
To assess the association between variation in retinal central subfield thickness (CSFT) with best-corrected visual acuity (BCVA) change in patients receiving vascular endothelial growth factor (VEGF) inhibitor therapy for neovascular age-related macular degeneration (nAMD).

Methods:
CSFT measurements were obtained from 141 eyes (total 1300 scans). SD of CSFT was calculated. The eyes were categorised into CSFT variation tertiles. Multiple linear regression was used to examine the association between the CSFT tertiles and BCVA change at 12 mo, adjusting for differences in baseline demographic and clinical characteristics.

Results:
At 12 mo, the mean BCVA of the high CSFT variation group (50.6 letters) was significantly lower than the low and moderate CSFT variation groups (57.5 and 59.8 letters, respectively), P = .02. The adjusted mean BCVA gains were +1.7, +7.2, and +7.8 letters in the high, moderate and low CSFT variation groups, respectively (P = .03).

Conclusions:
A greater variation in retinal thickness during VEGF inhibitor therapy for nAMD is associated with a less favourable visual outcome. CSFT stability is useful in prognosticating visual outcomes in VEGF inhibitor therapy for nAMD.
Original languageEnglish
JournalClinical and Experimental Ophthalmology
Early online date09 May 2021
DOIs
Publication statusEarly online date - 09 May 2021

Keywords

  • Ophthalmology

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