Association of antipsychotic drug-induced weight gain with a 5-HT2C receptor gene polymorphism

Gavin Reynolds, Z.J. Zhang, X.B. Zhang

Research output: Contribution to journalArticle

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Abstract

A side-effect of treatment with antipsychotic drugs for schizophrenia is increased body fat, which leads to further morbidity and poor adherence to treatment. The 5-hydroxytryptamine 2C receptor (5-HT2C) has been associated with this effect; we aimed to establish whether a genetic polymorphism of the promoter region of this receptor affects weight gain after drug treatment in first-episode patients with schizophrenia. We noted significantly less weight gain in patients with the -759T variant allele (p=0.0003) than in those without this allele, who were more likely to have substantial (>7%) weight gain (p=0.002). We have identified a genetic factor that is associated with antipsychotic drug-induced weight gain.
Original languageEnglish
Pages (from-to)2086-2087
Number of pages2
JournalThe Lancet
Volume359(9323)
Issue number9323
DOIs
Publication statusPublished - 15 Jun 2002

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Serotonin Receptors
Antipsychotic Agents
Weight Gain
Genes
Schizophrenia
Alleles
Genetic Polymorphisms
Genetic Promoter Regions
Adipose Tissue
Therapeutics
Morbidity
Pharmaceutical Preparations

Cite this

Reynolds, Gavin ; Zhang, Z.J. ; Zhang, X.B. / Association of antipsychotic drug-induced weight gain with a 5-HT2C receptor gene polymorphism. In: The Lancet. 2002 ; Vol. 359(9323), No. 9323. pp. 2086-2087.
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Association of antipsychotic drug-induced weight gain with a 5-HT2C receptor gene polymorphism. / Reynolds, Gavin; Zhang, Z.J.; Zhang, X.B.

In: The Lancet, Vol. 359(9323), No. 9323, 15.06.2002, p. 2086-2087.

Research output: Contribution to journalArticle

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