Association of Functional Heme Oxygenase-1 Gene Promoter Polymorphism with Renal Transplantation Outcomes

A.E. Courtney, P.T. McNamee, D. Middleton, Shirley Heggarty, Christopher Patterson, Alexander Maxwell

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Heme oxygenase-1 (HO-1) is a cytoprotective molecule and increased expression in experimental transplant models correlates with reduced graft injury. A functional dinucleotide repeat (GT)n polymorphism, within the HO-1 promoter, regulates gene expression; a short number of repeats (S-allele
Original languageEnglish
Pages (from-to)908-913
Number of pages6
JournalAmerican Journal of Transplantation
Volume7
Issue number4
DOIs
Publication statusPublished - Apr 2007

ASJC Scopus subject areas

  • Immunology

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