TY - JOUR
T1 - Association of Genetic Variants at 3q22 with Nephropathy in Patients with Type 1 Diabetes Mellitus
AU - He, B.
AU - Osterholm, A.M.
AU - Hoverfalt, A.
AU - Forsblom, C.
AU - Hjorleifsdottir, E.E.
AU - Nilsson, A.S.
AU - Parkkonen, M.
AU - Pitkaniemi, J.
AU - Hreidarsson, A.
AU - Sarti, C.
AU - McKnight, Amy Jayne
AU - Maxwell, Alexander
AU - Tuomilehto, J.
AU - Groop, P.H.
AU - Tryggvason, K.
PY - 2009/1/9
Y1 - 2009/1/9
N2 - Diabetic nephropathy (DN) is the primary cause of morbidity and mortality in patients with type 1 diabetes mellitus (T1DM) and affects about 30% of these patients. We have previously localized a DN locus on chromosome 3q with suggestive linkage in Finnish individuals. Linkage to this region has also been reported earlier by several other groups. To fine map this locus, we conducted a multistage case-control association study in T1DM patients, comprising 1822 cases with nephropathy and 1874 T1DM patients free of nephropathy, from Finland, Iceland, and the British Isles. At the screening stage, we genotyped 3072 tag SNPs, spanning a 28 Mb region, in 234 patients and 215 controls from Finland. SNPs that met the significance threshold of p
AB - Diabetic nephropathy (DN) is the primary cause of morbidity and mortality in patients with type 1 diabetes mellitus (T1DM) and affects about 30% of these patients. We have previously localized a DN locus on chromosome 3q with suggestive linkage in Finnish individuals. Linkage to this region has also been reported earlier by several other groups. To fine map this locus, we conducted a multistage case-control association study in T1DM patients, comprising 1822 cases with nephropathy and 1874 T1DM patients free of nephropathy, from Finland, Iceland, and the British Isles. At the screening stage, we genotyped 3072 tag SNPs, spanning a 28 Mb region, in 234 patients and 215 controls from Finland. SNPs that met the significance threshold of p
U2 - 10.1016/j.ajhg.2008.11.012
DO - 10.1016/j.ajhg.2008.11.012
M3 - Article
SN - 0002-9297
VL - 84
SP - 5
EP - 13
JO - The American Journal of Human Genetics
JF - The American Journal of Human Genetics
IS - 1
ER -