Association of MYH9/APOL1 with chronic kidney disease in a UK population

Amy Jayne McKnight; Seamus Duffy; Damian G Fogarty; Alexander P Maxwell

doi:10.1093/ndt/gfs181

Association of MYH9/APOL1 with chronic kidney disease in a UK population

Amy Jayne McKnight, Seamus Duffy, Damian G Fogarty, Alexander P Maxwell

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Abstract

Following the first report on the association between MYH9 gene variants and glomerular disorders [1], many studies have evaluated MYH9 loci for association with a range of kidney diseases [2]. In 2010, functional mutations in the adjacent APOL1 gene were identified as the primary variants responsible for associations with kidney disease that had previously been attributed to the MHY9 gene [3]. Nevertheless, several loci within MHY9 continue to be independently reported as risk factors for chronic kidney disease (CKD) [2, 4].

Original language	English
Pages (from-to)	3660
Journal	Nephrology Dialysis Transplantation
Volume	27
Issue number	9
DOIs	https://doi.org/10.1093/ndt/gfs181
Publication status	Published - Sep 2012

ASJC Scopus subject areas

Nephrology
Transplantation

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abstract = "Following the first report on the association between MYH9 gene variants and glomerular disorders [1], many studies have evaluated MYH9 loci for association with a range of kidney diseases [2]. In 2010, functional mutations in the adjacent APOL1 gene were identified as the primary variants responsible for associations with kidney disease that had previously been attributed to the MHY9 gene [3]. Nevertheless, several loci within MHY9 continue to be independently reported as risk factors for chronic kidney disease (CKD) [2, 4]. ",

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AB - Following the first report on the association between MYH9 gene variants and glomerular disorders [1], many studies have evaluated MYH9 loci for association with a range of kidney diseases [2]. In 2010, functional mutations in the adjacent APOL1 gene were identified as the primary variants responsible for associations with kidney disease that had previously been attributed to the MHY9 gene [3]. Nevertheless, several loci within MHY9 continue to be independently reported as risk factors for chronic kidney disease (CKD) [2, 4].

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